Objective: To establish an experimental animal model of chromic alcoholic fatty liver.Methods: Fifty three Wister rats were divided into four groups: control group and model groups(lower dose ethanol group?medium dose ethanol group and higher dose ethanol group).The rats in model groups were induced by ethanol intragastric infusion of 40%(v/v)ethanol orally [7g/(kg·d) for lower group?8 g/(kg·d) for medium group and 9 g/(kg·d) for higher group]

two times a day for the first 4 weeks.Ethanol intragastric infusion of 50%(v/v)ethanol orally [8 g/(kg·d) for lower group

9 g/(kg·d) for medium group and 10 g/(kg·d) for higher group]

two times a day for the second 4 weeks.Then

the liver was examined by Ultrasonography.The pathologic changes were observed and the amount of ALT?AST?γ-GT in serum were detected at the end of the eighth week.Results: At the end of eighth week

serum AST and γ-GT levels were increased significantly in model groups.The typical fatty liver pathologic changes of chronic alcoholism were observed in rats in medium and higher dose model groups.Conclusions: Experimental model of chronic alcoholic fatty liver can be established in rats with ethanol intragastric infusion.