Experimental study of inhibited cardiomyocyte apoptosis and improved cardiac function by simvastatin after myocardial infarction

YE Qiang; et al

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Experimental study of inhibited cardiomyocyte apoptosis and improved cardiac function by simvastatin after myocardial infarction

更新时间：2024-01-17

- Experimental study of inhibited cardiomyocyte apoptosis and improved cardiac function by simvastatin after myocardial infarction
- Journal of Chongqing Medical University Issue 4, Pages: 407-409(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院心内科
  2. 重庆医科大学附属第一医院心内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R542.22
- Published：2007，
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[1]叶强,覃数,雷寒,胥雪莲,蒋正英.辛伐他汀抑制心肌梗死后心肌细胞凋亡及改善心功能的实验研究[J].重庆医科大学学报,2007(04):407-409.

YE Qiang, et al. Experimental study of inhibited cardiomyocyte apoptosis and improved cardiac function by simvastatin after myocardial infarction. [J]. Journal of Chongqing Medical University (4):407-409(2007)
[1]叶强,覃数,雷寒,胥雪莲,蒋正英.辛伐他汀抑制心肌梗死后心肌细胞凋亡及改善心功能的实验研究[J].重庆医科大学学报,2007(04):407-409. DOI：

YE Qiang, et al. Experimental study of inhibited cardiomyocyte apoptosis and improved cardiac function by simvastatin after myocardial infarction. [J]. Journal of Chongqing Medical University (4):407-409(2007) DOI：

摘要

目的:观察辛伐他汀对心肌梗死后心肌细胞凋亡及心功能的影响。方法:结扎大鼠左冠状动脉前降支造成心肌梗死模型

实验组给予药物处理（辛伐他汀40mg/kg）

7天后

TUNEL法检测心肌组织中的凋亡心肌细胞

超声检测左心室功能参数

生化法检测血脂水平。结果:辛伐他汀组较心肌梗死组在梗死区、梗死周边区、远离梗死区凋亡心肌细胞显著减少（P<0.05）

左心室功能改善（P<0.05）

血脂水平没有显著性差异（P>0.05）。结论:辛伐他汀抑制心肌梗死后心肌细胞凋亡

改善心功能。

Abstract

Objective:To investigate the effect of simvastatin on cardiomyocyte apoptosis and cardiac dysfuction after myocardial infarction.Method:Simvastatin was administrated to the rats with myocardial infarction which was modeled by left anterior descending coronary artery ligation. After 7days

the apoptotic myocyte cells were quantified by TUNEL staining;left ventricular function index was measured by echocardiography and the level of serum lipid was measured by biochemical method.Results:Compared with infarction group

apoptotic myocyte cells in simvastatin group significantly decreased in infarction zone

border zone and non-infarction zone(P<0.05)

and left ventricular function was improved significantly(P<0.05).There was no difference in the level of serum lipid between the groups(P>0.05).Conclusion:Simvastatin inhibits cardiomyocyte apoptosis and improves cardiac function after myocardial infarction.

关键词

辛伐他汀心肌梗死凋亡

Keywords

simvastatinmyocardial infarctionapoptosis

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Department of Cardiology,College of Clinical Medicine,Chongqing Medical University

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