Establishment of adriamycin-induced dilated cardiomyopathy model in rabbits

BAI Yonghong; et al

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Establishment of adriamycin-induced dilated cardiomyopathy model in rabbits

更新时间：2024-01-17

- Establishment of adriamycin-induced dilated cardiomyopathy model in rabbits
- Journal of Chongqing Medical University Issue 6, Pages: 818-820(2006)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院超声室
  2. 重庆医科大学附属儿童医院心血管内科
  3. 重庆医科大学附属儿童医院儿科研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R-332
- Published：2006，
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[1]白永虹,沈兴,余更生,田杰,朱静.阿霉素诱导兔扩张型心肌病模型的建立[J].重庆医科大学学报,2006(06):818-820+891.

BAI Yonghong, et al. Establishment of adriamycin-induced dilated cardiomyopathy model in rabbits. [J]. Journal of Chongqing Medical University (6):818-820(2006)
[1]白永虹,沈兴,余更生,田杰,朱静.阿霉素诱导兔扩张型心肌病模型的建立[J].重庆医科大学学报,2006(06):818-820+891. DOI：

BAI Yonghong, et al. Establishment of adriamycin-induced dilated cardiomyopathy model in rabbits. [J]. Journal of Chongqing Medical University (6):818-820(2006) DOI：

摘要

目的:探讨阿霉素诱导兔扩张型心肌病模型的可行性。方法:26只兔经耳缘静脉注射阿霉素1m g（/kg.次）×2次/周×8周

用药结束后3周通过彩色超声心动图及病理检查对模型进行评估。结果:存活17只动物

与用药前相比其左室舒张末期内径（LVEDD）及收缩末期内径（LVESD）增大

射血分数（LVEF）及短轴缩短率（LVFS）减低

差别有显著意义（P<0.05）

病理检查符合心肌病样改变。结论:通过反复多次注射小剂量阿霉素可成功建立兔扩张性心肌病模型

其病理生理改变与人类临床相符。

Abstract

Objective:To explore the feasibility of adriamycin-induced dilated cardiomyopathy model in rabbits.Methods:26 rabbits were given 1mg.kg-1 body wt.of adriamycin intravenously twice a week for 8 weeks

then received echocardiography and histoligical examination after 3 weeks of final injection.Results: 17 rabbits survived.Compared to the baseline station

the value for the Left ventricular diastolic dimension(LVEDD) and the Left ventricular systolic dimension(LVESD) increased significantly

while the value for the Left ventricular ejection fraction(LVEF)and the Left ventricular short fraction(LVFS) decreased significantly after treated with adriamycin(P<0.05).Pathological examination demonstrated the change in myocardium of the treated rabbits consisted with the dilated cardiomyopathy in human patients.Conclusions:Intravenous injection of adriamycin can be used to induce dilated cardiomyopathy model in rabbits

and its physiopathologic characteristic closely resembles the human condition.

关键词

阿霉素扩张性心肌病兔模型

Keywords

AdriamycinDilated cardiomyopathyrabbitmodel

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