Clinical significance of serum chromogranin A in diagnosis of prostate cancer

WANG Ming; et al

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Clinical significance of serum chromogranin A in diagnosis of prostate cancer

更新时间：2024-01-17

- Clinical significance of serum chromogranin A in diagnosis of prostate cancer
- Journal of Chongqing Medical University Issue 4, Pages: 423-424(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院泌尿外科
  2. 重庆医科大学附属第一医院泌尿外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.25
- Published：2007，
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[1]王明,蔡运林.血清嗜铬粒蛋白A在前列腺癌诊断中的临床意义[J].重庆医科大学学报,2007(04):423-424+427.

WANG Ming, et al. Clinical significance of serum chromogranin A in diagnosis of prostate cancer. [J]. Journal of Chongqing Medical University (4):423-424(2007)
[1]王明,蔡运林.血清嗜铬粒蛋白A在前列腺癌诊断中的临床意义[J].重庆医科大学学报,2007(04):423-424+427. DOI：

WANG Ming, et al. Clinical significance of serum chromogranin A in diagnosis of prostate cancer. [J]. Journal of Chongqing Medical University (4):423-424(2007) DOI：

摘要

目的:探讨嗜铬粒蛋白A（CgA）在前列腺癌（PCa）中的表达及意义。方法:采用放射免疫方法测定27例前列腺癌、27例前列腺增生症患者及5例健康志愿者的血清CgA、前列腺特异性抗原（PSA）

分析各组CgA和PSA的水平。结果:PCa患者血清CgA（98.7±69.42）

与健康对照组（32.68±26.58）及BPH组（44.7±40.86）比较有显著意义（P<0.05）。血清CgA水平随癌分期的升高而升高

D期患者血清CgA水平明显高于正常对照组及其他各期PCa（P<0.01）。结论:血清CgA水平可应用于前列腺癌的诊断

尤其对PSA阴性或伴有远隔转移的病例具有重要意义。

Abstract

Objective:To evaluate the application of chromogranin A(CgA) as a marker in the diagnosis of prostate cancer. Methods:Serum CgA and serum prostate-specific antigen (PSA) were detected by immunoradiometric essay in 27 cases of prostatic carcinoma

27 cases of benign prostate hyperplasia (BPH)and 5 cases of healthy subjects. Results:Serum CgA(98.7±69.42) in patients with prostatic carcinoma was significantly higher than that in healthy subjects(32.68±26.58) and in patient with BPH(44.7±40.86)(P<0.05)

and it increased with escalation of clinical stage .Serum CgA at D stage was significantly higher than that in healthy subjects and patient at B and C stage of prostate cancer(P<0.01).The combined assay of serum PSA and CgA could raise the detection rate of prostate cancer .The sensitivity of parallel trials reached 85.2% and the specificity of serial trials reached 96%. Conclusions:The determination of serum levels of CgA is useful in the diagnosis of prostatic cancer

especially for patients who are PSA negative or have distant metastasis .

关键词

前列腺肿瘤嗜铬粒蛋白类放射免疫

Keywords

Prostatic neoplasmsChromograninsRadiommunoassay

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Related Institution

Department of Urology, College of Clinical Medicine, Chongqing Medical University

重庆医科大学临床学院泌尿外科

Department of Urology,the First Affiliated Hospital,Chongqing Medical University

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