Osteogenit growth peptide induces collagen Ⅰ in rat osteoblast-like cells

DING Bo; et al

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Osteogenit growth peptide induces collagen Ⅰ in rat osteoblast-like cells

更新时间：2024-01-17

- Osteogenit growth peptide induces collagen Ⅰ in rat osteoblast-like cells
- Journal of Chongqing Medical University Issue 9, Pages: 951-953(2007)
- 作者机构：
  
  1. 重庆医科大学附属口腔医院内科
  2. 重庆医科大学附属口腔医院内科,重庆,400015
- 作者简介：
- 基金信息：
- DOI：
  CLC： R782.2
- Published：2007，
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[1]丁波,黄姣,何斌.成骨生长肽对大鼠成骨细胞I型胶原蛋白的影响[J].重庆医科大学学报,2007(09):951-953.

DING Bo, et al. Osteogenit growth peptide induces collagen Ⅰ in rat osteoblast-like cells. [J]. Journal of Chongqing Medical University (9):951-953(2007)
[1]丁波,黄姣,何斌.成骨生长肽对大鼠成骨细胞I型胶原蛋白的影响[J].重庆医科大学学报,2007(09):951-953. DOI：

DING Bo, et al. Osteogenit growth peptide induces collagen Ⅰ in rat osteoblast-like cells. [J]. Journal of Chongqing Medical University (9):951-953(2007) DOI：

摘要

目的:研究成骨生长肽OGP在体外对大鼠颅盖骨成骨细胞I型胶原蛋白的影响。方法:在体外培养的新生大鼠颅盖骨成骨细胞中加入浓度为10-11～10-7mol/L的OGP

处理7天后收集细胞爬片

采用SABC法行细胞免疫化学染色

通过图像分析系统观察不同OGP作用后

成骨细胞胶原蛋白的变化情况。结果:OGP作用于成骨细胞后

I型胶原蛋白表达明显增强

其中OGP浓度为10-9mol/L时促进作用最为明显。结论:OGP可促进成骨细胞I型胶原蛋白的表达。

Abstract

Objective:To elucidate the effect of osteogenic growth peptide(OGP) on the collagen I in cultured rat osteoblast-like cells.Method:Osteoblast-like cells were treated with 10-11~10-7mol/L of OGP for 7d respectively.Then cells were processed for SABC stain and examination of the collagen I.Microscopy and analysis system was used to investigate the changes of collagen I.Result:OGP can promote the expression of collagen I in rat osteoblast-like cells.The most best concentration of OGP is 10-9mol/L.Conclusion:Our results demonstrate that OGP at 10-9mol/L may stimulate the expression of collagen I in rat osteoblast-like cells in vitro.

关键词

成骨生长肽成骨细胞I型胶原蛋白

Keywords

OGPosteoblastCollagen I

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