Determination of the content of ferulic acid in Xiaojin Wan soft capsule by HPLC

WANG Xin; et al

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Determination of the content of ferulic acid in Xiaojin Wan soft capsule by HPLC

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- Determination of the content of ferulic acid in Xiaojin Wan soft capsule by HPLC
- Journal of Chongqing Medical University Issue 3, Pages: 282-283(2007)
- 作者机构：
  
  1. 重庆医科大学药学院生药教研室
  2. 重庆医科大学药学院生药教研室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R286.0
- Published：2007，
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[1]王欣,刘新.HPLC法测定小金丸软胶囊中阿魏酸的含量[J].重庆医科大学学报,2007(03):282-283+289.

WANG Xin, et al. Determination of the content of ferulic acid in Xiaojin Wan soft capsule by HPLC. [J]. Journal of Chongqing Medical University (3):282-283(2007)
[1]王欣,刘新.HPLC法测定小金丸软胶囊中阿魏酸的含量[J].重庆医科大学学报,2007(03):282-283+289. DOI：

WANG Xin, et al. Determination of the content of ferulic acid in Xiaojin Wan soft capsule by HPLC. [J]. Journal of Chongqing Medical University (3):282-283(2007) DOI：

摘要

目的:建立小金丸软胶囊中阿魏酸的HPLC含量测定方法。方法:采用DiamonsilTMC1（84.6×250mm

5μm）色谱柱

流动相为甲醇:1%醋酸水溶液（25:75）

流速为1.0ml/min

柱温25℃

检测波长为320nm。结果:阿魏酸在3￣18μg/ml与其峰面积线性关系良好

回归方程为Y=100708.7X+24（r=0.9991）

平均回收率为100.6%（RSD=1.86%

n=5）。结论:该方法灵敏度高

准确

重现性好

可作为小金丸软胶囊中阿魏酸含量测定方法。

Abstract

Objective:To establish a method for content determination of ferulic acid in Xiaojin Wan soft capsule by high performance liquid chromatography(HPLC).Methods:Analysis was carried out on Shimadzu LC-2010A HPLC.The separation was performed on DiamonsilTM C18 column(4.6×250mm

5μm)

with methanol:1% acetic acid(25:75) as mobile phase

the flow rate was 1.0ml/min

column temperature was 25℃ and the detection wavelength was 320nm.Results:A good linear relationship was found within the range of 3~18μg/ml

Regression equation was Y=100708.7X+24(r =0.9991)and the average recovery was 101.1%(RSD=1.86%

n=5).Conclusion:This method was highly sensitive

accurate and well represented

which could be used to determine the content of ferulic acid in Xiaojin Wan soft capsule.

关键词

小金丸软胶囊阿魏酸高效液相色谱法

Keywords

Xiaojin Wan soft capsuleFerulic acidhigh performance liquid chromatography(HPLC)

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Related Institution

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