Study on in vitro antibacterial activity of prulifloxacin against pathogenic bacteria of respiratory tract and urinary tract infections

LIU Chengwei; et al

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Study on in vitro antibacterial activity of prulifloxacin against pathogenic bacteria of respiratory tract and urinary tract infections

更新时间：2024-01-17

- Study on in vitro antibacterial activity of prulifloxacin against pathogenic bacteria of respiratory tract and urinary tract infections
- Journal of Chongqing Medical University Issue 3, Pages: 284-286(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院传染病寄生虫病研究所重庆市传染病寄生虫病学重点实验室
  2. 重庆医科大学附属第一医院感染科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R96
- Published：2007，
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[1]刘成伟,黄文祥,卓超,李崇智,余登高,郑行萍.普卢利沙星对呼吸道和泌尿道致病菌的体外抗菌活性研究[J].重庆医科大学学报,2007(03):284-286+305.

LIU Chengwei, et al. Study on in vitro antibacterial activity of prulifloxacin against pathogenic bacteria of respiratory tract and urinary tract infections. [J]. Journal of Chongqing Medical University (3):284-286(2007)
[1]刘成伟,黄文祥,卓超,李崇智,余登高,郑行萍.普卢利沙星对呼吸道和泌尿道致病菌的体外抗菌活性研究[J].重庆医科大学学报,2007(03):284-286+305. DOI：

LIU Chengwei, et al. Study on in vitro antibacterial activity of prulifloxacin against pathogenic bacteria of respiratory tract and urinary tract infections. [J]. Journal of Chongqing Medical University (3):284-286(2007) DOI：

摘要

目的:研究普卢利沙星对呼吸道和泌尿道致病菌的体外抗菌活性。方法:采用琼脂二倍稀释法

测定普卢利沙星与左氧氟沙星对221株呼吸道和泌尿道致病菌的最低抑菌浓度（MIC）。结果:普卢利沙星对所有测试菌的MIC50、MIC90和敏感率范围分别为≤0.03-1μg/ml、0.5-4μg/ml及67%-100%

左氧氟沙星分别为0.125-2μg/ml、0.5-8μg/ml及61%-100%。普卢利沙星对大肠埃希菌、阴沟肠杆菌、铜绿假单胞菌和卡他莫拉菌的MIC90是左氧氟沙星的MIC90的1/2;对肺炎克雷伯菌、变形杆菌、表皮葡萄球菌、肺炎链球菌和粪肠球菌的MIC90与左氧氟沙星的MIC90相等;对流感嗜血杆菌和金黄色葡萄球菌的MIC90是左氧氟沙星的MIC90的2倍。结论:普卢利沙星对呼吸道和泌尿道致病菌均具有抗菌活性。

Abstract

Object:To study in vitro antibacterial activity of prulifloxacin against pathogenic bacteria of respiratory tract and urinary tract infections.Methods:The minimum inhibitory concentration(MIC) of prulifloxacin and levofloxacin against 221 pathogenic bacteria of respiratory tract and urinary tract infections was determined by agar dilution method.Results:MIC50

MIC90 and the susceptible rate of prulifloxacin were≤0.03~1μg/ml

0.5~4μg/ml and 67%~100%

respectively.Those of levofloxacin were 0.125~2μg/ml

0.5~8μg/ml and 61%~100%

respectively.MIC90 of prulifloxacin was half that of levofloxacin against Escherichia coli

Enterobacter cloacae

Pseudomonas aeruginosa and Moraxella catarrhalis.MIC90 of prulifloxacin was equal to that of levofloxacin against Klebsiella pneumoniae

Proteus spp

Staphlococcus epidermidis

Streptococcus pneumoniae and Enterococus faecalis.MIC90 of prulifloxacin was two times that of levofloxacin against Haemophilus influenzae and Staphylococcus aureus.Conclusion:Prulifloxacin had a broad-spectrum antibacterial activity against pathogenic bacteria of respiratory tract and urinary tract infections.

关键词

普卢利沙星左氧氟沙星体外抗菌活性

Keywords

PrulifloxacinLevofloxacinIn vitro antibacterial activity

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