Objective:To study the expression of mitosis checkpoint gene hsMAD2 in colorectal cancer. Methods:The expression of hsMAD2 gene mRNA in colorectal cancer and normal colorectal tissue of 18 cases was quantitatively detected by RT-PCR. Results:The ratio of hsMAD2 mRNA/ GAPDH mRNA in colorectal cancer and normal colorectal tissue were 0.1235±0.0752 and 0.0312±0.0598

respectively. The results suggested that the expression of hsMAD2 mRNA in colorectal cancer were significant higher than in normal colorectal tissue(P<0.05). Conclusion:Compared with normal colorectal tissue

the expression of hsMAD2 mRNA in colorectal cancer was markedly increased. This probably indicated that to up-regulate the expression of hsMAD2 mRNA in colorectal cancer may be a very effective to abnormal proliferation of colorectal cancer cells. And hsMAD2 gene as a related gene to colorectal cancer can play an important role in colorectal cancer pathogenesis.