Effect of Hypoxia-inducible factor-1 alpha on the radiosensitivity of rat cervical carcinoma

LIU Fangxin; et al

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Effect of Hypoxia-inducible factor-1 alpha on the radiosensitivity of rat cervical carcinoma

更新时间：2024-01-17

- Effect of Hypoxia-inducible factor-1 alpha on the radiosensitivity of rat cervical carcinoma
- Journal of Chongqing Medical University Issue 3, Pages: 250-252(2007)
- 作者机构：
  
  1. 重庆医科大学基础医学院放射医学教研室
  2. 解放军第181医院妇幼中心
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.33
- Published：2007，
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[1]刘方欣,张玉诺,李晓愚,任庆兰,彭志平,李少林.低氧诱导因子1α对小鼠宫颈癌放射敏感性的影响[J].重庆医科大学学报,2007(03):250-252+278.

LIU Fangxin, et al. Effect of Hypoxia-inducible factor-1 alpha on the radiosensitivity of rat cervical carcinoma. [J]. Journal of Chongqing Medical University (3):250-252(2007)
[1]刘方欣,张玉诺,李晓愚,任庆兰,彭志平,李少林.低氧诱导因子1α对小鼠宫颈癌放射敏感性的影响[J].重庆医科大学学报,2007(03):250-252+278. DOI：

LIU Fangxin, et al. Effect of Hypoxia-inducible factor-1 alpha on the radiosensitivity of rat cervical carcinoma. [J]. Journal of Chongqing Medical University (3):250-252(2007) DOI：

摘要

目的:探讨低氧诱导因子1α（HIF-1α）对小鼠宫颈癌皮下移植瘤放射敏感性的影响

探讨其可能的机制。方法:建立宫颈癌皮下移植瘤模型

随机分为对照组、单次γ射线大剂量照射组、小剂量分次照射组、大剂量照射联合高压氧组、小剂量分次照射联合高压氧组

采用不同的方案进行体外放射治疗。免疫组化法测定放射治疗后移植瘤内的HIF-1α、bcl-2的表达水平

观察各γ射线处理组照射后移植瘤的抑瘤率

并对HIF-1α与bcl-2的表达及抑瘤率进行相关性分析。结果:HIF-1α的表达与移植瘤抑瘤率呈负相关（r=-0.514

P<0.05）;与Bcl-2表达无明显相关关系。结论:抑制HIF-1α的表达可提高肿瘤对放射治疗的敏感性

该效应可能与Bcl-2表达无关。

Abstract

Objective:To study the effect of Hypoxia-inducible factor-1 alpha(HIF-1α)on the radiosensitivity of rat cervical carcinoma and discuss the possible mechanism.Methods:The transplantation tumor model of cervical carcinoma was established. 77 rats were randomly divided into five groups:control group

the large fraction irradiation group

the small fraction irradiation group

the large fraction irradiation combining HBO group and the low dose irradiation combining HBO group.Expressions of HIF-1α and bcl-2 in transplantation tumor after treatment were detected by immunohistochemical staining

and the tumor inhibitory rate by the change of tumor volume.The correlation between expressions of HIF-1 α and bcl-2(and tumor inhibitory rate)was also observed.Results:Expression of HIF-1 α and carcinoma growth inhibitory rate showed a reverse correlation(r=-5.147

P<0.05).No correlation was found between the expression of HIF-1 α and bcl-2.Conclusions:Inhibiting the HIF-1α expression could effectively promote the radiosensitivity of rat cervical carcinoma without impacting the expression of Bcl-2.

关键词

低氧诱导因子1α放射敏感性宫颈癌

Keywords

Hypoxia-inducible factor-1α(HIF-1α)radiosensitivitycervical carcinoma

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