Correlation between oral glucose tolerance test and liver function in cirrhotic patients

KANG Changming; et al

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Correlation between oral glucose tolerance test and liver function in cirrhotic patients

更新时间：2024-01-17

- Correlation between oral glucose tolerance test and liver function in cirrhotic patients
- Journal of Chongqing Medical University Issue 6, Pages: 657-658(2007)
- 作者机构：
  
  1. 四川省人民医院草堂分院内科
  2. 四川省人民医院草堂分院内科,四川,成都,610071
- 作者简介：
- 基金信息：
- DOI：
  CLC： R575.2
- Published：2007，
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[1]康长明,曾庆华,刁瑞容.肝硬化患者口服葡萄糖耐量试验的变化[J].重庆医科大学学报,2007(06):657-658+661.

KANG Changming, et al. Correlation between oral glucose tolerance test and liver function in cirrhotic patients. [J]. Journal of Chongqing Medical University (6):657-658(2007)
[1]康长明,曾庆华,刁瑞容.肝硬化患者口服葡萄糖耐量试验的变化[J].重庆医科大学学报,2007(06):657-658+661. DOI：

KANG Changming, et al. Correlation between oral glucose tolerance test and liver function in cirrhotic patients. [J]. Journal of Chongqing Medical University (6):657-658(2007) DOI：

摘要

目的:探讨口服葡萄糖耐量试验（OGTT）血糖变化与肝硬化患者肝功能状况的关系。方法:肝硬化患者按child-Pugh肝功能分级分为:A级;B级;C级3组

健康人为对照组。行OGTT

采用葡萄糖氧化酶法测定血糖浓度。结果:60min和120min血糖浓度均显著高于对照组（P<0.05）

120min血糖与血清白蛋白浓度呈显著负相关（P<0.001）

与血清总胆红素浓度、凝血酶原延长时间等呈显著正相关（P<0.001）。结论:OGTT的120min血糖值与肝硬化患者的肝功能状况密切相关

是反映肝硬化患者肝脏处理糖负荷能力的良好指标。

Abstract

Objective:To investigate the correlation between the change of blood glucose and liver function after oral glucose tolerance test in cirrhotic patients.Methods:36 cirrhotic patients were classified into A

B and C groups according to Child-Pugh score.36 cirrhotic patients and 12 normal controls were given oral glucose tolerance test(OGTT)of 75g glucose after over night fasting.Venous blood samples OGTT 0

120 and 180 minutes were obtained.Results: The OGTT 60 and 120 minute’s blood glucose values in total cirrhotic group were significantly higher than that in the controls(P<0.005).And the OGTT 60 and 120 minute’s blood glucose values had an increasing tendency

as liver function got bad.The OGTT 120 minute’s blood glucose values had a significant correlation with ALB(r=-0.53

P<0.001).TBIL(r=0.43

P<0.001).prolonged PT(r=0.56

P<0.001).child-Pugh score(r=-0.54

P<0.001).Conclusion:The OGTT 120 minute’s blood glucose values had a significant correlation with liver function in cirrhotic patients.

关键词

肝硬化口服葡萄糖耐量试验肝功能

Keywords

CirrhoticOral glucose toleranceliver function

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Related Institution

Department of Endocrinology and Metabolism，The Affiliated Hospital of Kunming University of Science and Technology/The First People’s Hospital of Yunnan Province

Depatment of Hepatobiliary Surgery，the Affiliated Hospital，Luzhou Medical College

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