Effects of Lycium Barbarum Polysaccharide on the expression of hepatocyte cytochrome P4503A in rats with alcoholic fatty liver

GU Sai; et al

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Effects of Lycium Barbarum Polysaccharide on the expression of hepatocyte cytochrome P4503A in rats with alcoholic fatty liver

更新时间：2024-01-17

- Effects of Lycium Barbarum Polysaccharide on the expression of hepatocyte cytochrome P4503A in rats with alcoholic fatty liver
- Journal of Chongqing Medical University Issue 4, Pages: 371-375(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院消化内科
  2. 重庆医科大学组胚教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2007，
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[1]古赛,姜蓉.枸杞多糖对酒精性脂肪肝大鼠肝细胞色素P4503A的影响[J].重庆医科大学学报,2007(04):371-375.

GU Sai, et al. Effects of Lycium Barbarum Polysaccharide on the expression of hepatocyte cytochrome P4503A in rats with alcoholic fatty liver. [J]. Journal of Chongqing Medical University (4):371-375(2007)
[1]古赛,姜蓉.枸杞多糖对酒精性脂肪肝大鼠肝细胞色素P4503A的影响[J].重庆医科大学学报,2007(04):371-375. DOI：

GU Sai, et al. Effects of Lycium Barbarum Polysaccharide on the expression of hepatocyte cytochrome P4503A in rats with alcoholic fatty liver. [J]. Journal of Chongqing Medical University (4):371-375(2007) DOI：

摘要

目的:通过观察枸杞多糖（LBP）对酒精性脂肪肝（AFL）大鼠肝细胞色素P4503A基因和活性的影响

揭示其部分治疗机制。方法:用乙醇灌胃10周造成大鼠慢性AFL模型

再用5%和10%的LBP治疗10周

10%阿托莫兰（GSH）治疗组和戒酒组作为阳性对照

作治疗前后比较:肝脏病理形态

肝匀浆还原型谷光甘肽GSH、丙二醛MDA含量

肝细胞色素P4503A（CYP3A）活性及基因表达水平。结果:LBP能明显改善酒精所致大鼠肝脏脂肪性病理变化

增加GSH含量

减少MDA产生

抑制CYP3A活性和基因表达

其改善脂肪病变与阿托莫兰组无显著差异

优于单纯戒酒组。结论:LBP抑制CYP3A活性及基因表达

减轻脂质过氧化

有效治疗AFL。

Abstract

Objective:To study the effect of Lycium Barbarum Polysaccharide(LBP) on the activity and gene expression of hepatocyte cytochrome P4503A(CYP3A) in rat model with alcoholic fatty liver (AFL). Methods:The AFL rats models were established by ethanol intragastric infusion for ten weeks. Then

those AFL model rats were treated with 5% and 10% LBP and 10% GSH intragastric infusion. Liver pathologic changes were observed and the activity of CYP3A and its gene expression as well as the contents of malondialdehyde(MDA) and glutathione(GSH) in liver were detected and compared among the control group

treatment group and abstinence treatment group. Results:Fatty degeneration in liver recovered normally in the LBP treatment groups. LBP could inhibit the expression of CYP3A gene

reduce the activity of CYP3A and the content of MDA

and increase the content of GSH. The curative effect of LBP was not significantly different from that of GSH

but greater than that of abstinence treatment. Conclusion:LBP can prevent AFL through markedly inhibiting the hepatocyte CYP3A activity and gene expression.

关键词

酒精性脂肪肝枸杞多糖治疗细胞色素P4503A

Keywords

alcoholic fatty liverLyceum Barbarum PolysaccharidetreatmentCytochrome P4503A

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Related Institution

Department of Gastroenterology,the First Affiliated Hospital,Chongqing Medical University

Department of Traditional Chinese Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

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Department of Respiratory Medicine，Children’s Hospital，Zhejiang University School of Medicine/ National Clinical Research Center for Child Health

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