Objective:To evaluate the effect of procyanidins in protecting lens against oxidative stress.Methods:Rabbit’s lenses cultured in vitro were divided into 4 groups:Feton model group(oxidative stress group)

groups treated with 100mg/L vitamin C

100mg/L vitamin E

and with PC(50mg、100mg/L、200mg/L).After 24 hours of incubation

alteration of opacity was observed by photography and picture analysis;the histomorphology of lenses were examined under light microscope. The levels of slo-Prot

SOD

and MDA were tested.Results:The transparency of a1l lenses were different.The relative gray scale in Feton model and vitamin C group were lower than that in other groups(P<0.05). Compared with other groups

the oxidative damage of lenses in PC group was light

but slo-Prot levels and SOD activities increased

while MDA level decreased significantly(P<0.01). Conclusion:PC can protect lens against oxidative stress and inhibit lipid peroxidation activity.