Relationship between expression of p53、cerbB-2 and the effect of neoadjuvant chemotherapy using taxinol and epirubicin in breast cancer

FAN Qingdong; et al

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Relationship between expression of p53、cerbB-2 and the effect of neoadjuvant chemotherapy using taxinol and epirubicin in breast cancer

更新时间：2024-01-17

- Relationship between expression of p53、cerbB-2 and the effect of neoadjuvant chemotherapy using taxinol and epirubicin in breast cancer
- Journal of Chongqing Medical University Issue 10, Pages: 1059-1061(2007)
- 作者机构：
  
  1. 第三军医大学西南医院乳腺中心
  2. 第三军医大学西南医院乳腺中心,重庆,400038
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9
- Published：2007，
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[1]凡庆东,姜军,杨新华,范林军,周艳.乳腺癌p53、cerbB-2表达与TE方案新辅助化疗疗效的关系[J].重庆医科大学学报,2007(10):1059-1061+1077.

FAN Qingdong, et al. Relationship between expression of p53、cerbB-2 and the effect of neoadjuvant chemotherapy using taxinol and epirubicin in breast cancer. [J]. Journal of Chongqing Medical University (10):1059-1061(2007)
[1]凡庆东,姜军,杨新华,范林军,周艳.乳腺癌p53、cerbB-2表达与TE方案新辅助化疗疗效的关系[J].重庆医科大学学报,2007(10):1059-1061+1077. DOI：

FAN Qingdong, et al. Relationship between expression of p53、cerbB-2 and the effect of neoadjuvant chemotherapy using taxinol and epirubicin in breast cancer. [J]. Journal of Chongqing Medical University (10):1059-1061(2007) DOI：

摘要

目的:分析乳腺癌p53、cerbB-2表达与TE方案新辅助化疗的疗效关系

寻找指导治疗、判断疗效的分子生物学指标。方法:57例诊断为乳腺癌患者化疗前穿刺标本

应用免疫组化s-p法检测p53、cerbB-2蛋白表达水平。结果:（1）TE方案新辅助化疗有效率为73.7%

化疗效果与肿瘤类型、临床分期、cerbB-2表达均不相关

p53表达阳性化疗有效率59.1%

p53表达阴性化疗有效率82.9%

有显著性差异（P<0.05）。（2）在临床完全缓解（cCR）11例中

p53阳性仅1例

p53阴性10例（P<0.05）。结论:p53表达阴性化疗有效率高

伴明显的临床完全缓解率

p53表达状态可以作为判断疗效的指标。

Abstract

Objective:To study the correlation of p53、cerbB-2 expression in breast cancer with the clinical response to TE regimen neoadjuvant chemotherapy

and search for biological markers to guide therapy and predict effect of neoadjuvant chemotherapy. Methods:The expression of the p53

cerbB-2 was examined by immunohistoehemical assay in samples of breast cancer tissue before neoadjuvant chemotherapy which taken from 57 case of breast cancer patients.Results:The overall response rate to neoadjuvant chemotherapy was 73.7%.The effect of neoadjuvant chemotherapy was not related to types of tumor and TNM stage. The effect of neoadjuvant chemotherapy had a significantly negative correlation with p53 expression. There was no significant diference between the response to neoadjuvant chemotherapy and cerbB-2 expression.Of the 11 patients who obtained a complete clinical response

Only one was classified as p53 positive(P<0.05).Conclusion:A negative expression of p53 indicates a higher chance of responding to this regimen. The p53 status may be used as a biological marker to predict the effect of neoadjuvant chemotherapy.

关键词

乳腺癌新辅助化疗p53cerbB-2

Keywords

breast cancerneoadjuvant chemotherapyp53cerbB-2

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