An study of the "staircase test" evaluating forelimb function of rat model with focal cerebral ischemia

GONG Biao; et al

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An study of the "staircase test" evaluating forelimb function of rat model with focal cerebral ischemia

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- An study of the "staircase test" evaluating forelimb function of rat model with focal cerebral ischemia
- Journal of Chongqing Medical University Issue 10, Pages: 1055-1058(2007)
- 作者机构：
  
  1. 重庆医科大学中医药学院针灸教研室
  2. 重庆医科大学附属第二医院神经内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R743.3
- Published：2007，
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[1]龚标,李长清,任庆华,李静,黄思琴.“楼梯测试”评价局灶性脑梗死大鼠前肢功能研究[J].重庆医科大学学报,2007(10):1055-1058.

GONG Biao, et al. An study of the "staircase test" evaluating forelimb function of rat model with focal cerebral ischemia. [J]. Journal of Chongqing Medical University (10):1055-1058(2007)
[1]龚标,李长清,任庆华,李静,黄思琴.“楼梯测试”评价局灶性脑梗死大鼠前肢功能研究[J].重庆医科大学学报,2007(10):1055-1058. DOI：

GONG Biao, et al. An study of the "staircase test" evaluating forelimb function of rat model with focal cerebral ischemia. [J]. Journal of Chongqing Medical University (10):1055-1058(2007) DOI：

摘要

目的:探索"楼梯测试"评价局灶性脑梗死大鼠前肢延伸和抓取能力的有效应性。方法:实验选择左利爪SD大鼠18只

随机分为正常组、假手术组和手术组

每组6只;正常组不作任何手术处理

假手术组仅作颈外动脉结扎

手术组用线栓法制成局灶性脑梗死大鼠模型;用树脂玻璃材料做成的可抽取楼梯测试盒比较3组大鼠前肢的延伸和抓取能力。结果:所有大鼠经过适当训练均能完成"楼梯测试"实验

3组在训练的第7天组间无统计学差异（P>0.05）;正常组和假手术组在3个时间点的抓取能力均无统计学差异（P>0.05）;手术组的术后第7天和第14天的抓取能力与术前第1天比较均有显著性差异（P<0.05）

术后第7天和第14天抓取能力无统计学差异（P>0.05）。结论:"楼梯测试"能简单和有效的评估局灶性脑梗死大鼠前肢独立伸展技术能力

能客观定量地反映实验大鼠的前爪功能

是研究实验干预脑梗死大鼠前肢功能恢复的方法学手段之一。

Abstract

Objective:To probe the effect of the "staircase test" evaluating the forelimb reaching and grasping function of rat model with focal cerebral ischemia.Method:The 18 SD rats were divided into 3 groups randomly:normal group

sham-operation group

and operation group

6 in each group.Normal group got no operation

sham-operation group just got the ligation of external carotid artery

and operation group was made to the model of focal cerebral ischemia by suture methods.To compare the reaching and grasping effect of the 3 groups forelimb

The removable staircase test made of plexiglas would compare the reaching and grasping effect of the 3 groups rat forelimb.Result:All the rats finished the"staircase test"through suitable exercise.There is no statistical significance among the three groups on the 7th day (P>0.05);there is no statistical significance about grasping abilities between normal group and sham-operation group at 3 time points(P>0.05);the grasping ability of the operation group on the 7th and 14th after operation is more significant than the one of the fist day before operation(P<0.05)

but the grasping ability on the 7th and the 14th is no statistical significance after operation(P>0.05). Conclusion:The "staircase test" can evaluate the forelimb independent reaching ability of the rat model with focal cerebral ischemia effectively and simply

it also is credible parameter index for the forelimb reaching ability of rat model with focal cerebral ischemia and one of methodology for researching intervening rats model with focal cerebral ischemia by experiment for resumption.

关键词

楼梯测试局灶性脑梗死大鼠前肢抓取能力

Keywords

Staircase testFocal cerebral ischemiaratForelimbGrasping skill

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