Expression characteristics of 5 drug-resistance genes in 6 common adult malignant tumors

ZHANG Yan; et al

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Expression characteristics of 5 drug-resistance genes in 6 common adult malignant tumors

更新时间：2024-01-17

- Expression characteristics of 5 drug-resistance genes in 6 common adult malignant tumors
- Journal of Chongqing Medical University Issue 10, Pages: 1023-1026(2007)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院基因表达调控实验室
  2. 重庆医科大学附属儿童医院基因表达调控实验室,重庆,400014
- 作者简介：
- 基金信息：
- DOI：
  CLC： R730.5
- Published：2007，
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[1]张燕,金先庆,赵珍珍,宿玉玺.5种耐药基因在成人常见恶性肿瘤中的表达特点[J].重庆医科大学学报,2007(10):1023-1026+1031.

ZHANG Yan, et al. Expression characteristics of 5 drug-resistance genes in 6 common adult malignant tumors. [J]. Journal of Chongqing Medical University (10):1023-1026(2007)
[1]张燕,金先庆,赵珍珍,宿玉玺.5种耐药基因在成人常见恶性肿瘤中的表达特点[J].重庆医科大学学报,2007(10):1023-1026+1031. DOI：

ZHANG Yan, et al. Expression characteristics of 5 drug-resistance genes in 6 common adult malignant tumors. [J]. Journal of Chongqing Medical University (10):1023-1026(2007) DOI：

摘要

目的:通过对成人肝癌、肺癌、胃癌、肠癌、乳腺癌、卵巢癌5种耐药基因蛋白的检测

了解常见恶性肿瘤组织耐药基因表达的一般规律和特点。方法:应用SP免疫组织化学法检测120例成人常见肿瘤标本P-gp、MRP、LRP、GST-π、Topo-Ⅱ的表达。结果:1.在6种常见肿瘤中P-gp、MRP、LRP、GST-π相对高表达

而Topo-Ⅱ相对低表达。2.肝癌的5种耐药基因蛋白表达均偏高。3.2种和2种以上耐药基因的共表达率达95.83%

其中5种耐药基因共表达率达21.67%。结论:P-gp、MRP、LRP、GST-π、Topo-Ⅱ均不同程度的参与了肿瘤耐药机制

临床上可作为指导用药的综合指标

实现个体化化疗。

Abstract

Objective:To investigate the expression of five drug resistance genes in hepato cellular cancer

lung cancer

stomach cancer

colorectal cancer

ovarian cancer

breast cancer tissue. Methods:The expression of P-gp

MRP

LRP

GST-π

Topo-Ⅱ in 120 cases of malignant tumors were examined by immunohistochemistry stain. Results: 1. The expression of P-gp

MRP

LRP

GST-π in the 6 common cancers were relatively high

while Topo-Ⅱ was relatively low. 2. P-gp

MRP

LRP

GST-π

Topo-Ⅱ were all high expressed in hepatocellular cancer. 3. The coexpression rate of two and more genes was 95.83%

the coexpression rate of five genes was 21.67%. Conclusion:P-gp

MRP

LRP

GST-π

Topo-Ⅱ are associated with multidrug resistance in different degree

which can be regarded as valuable indicators for the decision of individual chemotherapeutic program.

关键词

耐药基因肿瘤多药耐药表达

Keywords

Drug resistance genecancermultidrug resistanceexpression

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Related Institution

Department of Oncology，Nantong Tumor Hospital/Tumor Hospital Affiliated to Nantong University

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Department of Pathology， Nantong Tumor Hospital/Tumor Hospital Affiliated to Nantong University

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Laboratory of Basic Medical Science,General Hospital of Southern Theater Command of PLA

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