The role of Cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of breast cancer

GAO Yanchun; et al

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The role of Cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of breast cancer

更新时间：2024-01-17

- The role of Cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of breast cancer
- Journal of Chongqing Medical University Issue 9, Pages: 915-918(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌外科
  2. 重庆医科大学附属第一医院内分泌外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9
- Published：2007，
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[1]高砚春,吴诚义.COX-2、VEGF-C在乳腺癌中的表达及与淋巴转移的关系[J].重庆医科大学学报,2007(09):915-918.

GAO Yanchun, et al. The role of Cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of breast cancer. [J]. Journal of Chongqing Medical University (9):915-918(2007)
[1]高砚春,吴诚义.COX-2、VEGF-C在乳腺癌中的表达及与淋巴转移的关系[J].重庆医科大学学报,2007(09):915-918. DOI：

GAO Yanchun, et al. The role of Cyclooxygenase-2 and vascular endothelial growth factor-C in lymphatic metastasis of breast cancer. [J]. Journal of Chongqing Medical University (9):915-918(2007) DOI：

摘要

目的:探讨环氧化酶-2（COX-2）、血管内皮生长因子C（VEGF-C）在乳腺癌中的表达及其与乳腺癌淋巴结转移的关系。方法:采用免疫组化法（SP法）

检测45例乳腺癌组织中COX-2、VEGF-C的蛋白表达情况

分析其与患者年龄、肿瘤大小、雌、孕激素受体状况、临床分期、腋窝淋巴结转移的关系。结果:在45例乳腺癌组织中

COX-2、VEGF-C蛋白表达的阳性率分别为84.4%（38/45）和71.1%（32/45）。二者在Ⅲ+Ⅳ期乳腺癌中的阳性表达率明显高于Ⅰ+Ⅱ期乳腺癌

分别为93.3%:66.7%和83.3%:46.7%（P<0.05）

在腋窝淋巴结阳性组表达率高于腋窝淋巴结阴性组

分别为92.9%:70.6%和82.2%:52.9%（P<0.05）

但与患者年龄、肿瘤大小、雌激素、孕激素受体状况等无明显相关性（P>0.05）。COX-2阳性的乳腺癌组织VEGF-C表达率高于COX-2阴性组

分别为76.2%:43.6%（P<0.05）。COX-2与VEGF-C在乳腺癌中的表达成正相关（r=0.579

P<0.05）。结论:乳腺癌组织中

COX-2、VEGF-C表达均与肿瘤临床分期、腋窝淋巴结转移呈明显相关关系。COX-2可促使肿瘤细胞分泌VEGF-C

促进淋巴结转移增加。

Abstract

Objective: To investigate the expression of Cyclooxygenase-2(COX-2) and vascular endothelial growth factor-C (VEGF-C) proteins

and their relationship with lymphatic metastasis of breast cancer.Methods: Immunohistochemical staining was used to detect the expression of COX-2 and VEGF-C proteins in 45 cases of breast cancer.The relationship was analyzed between the expression of VEGF-C

COX-2 and age

tumor size

the protein expression of estrogen receptor(ER) and progesterone receptor(PR)

clinic phase

axillary lymph node metastasis.Results: The expression rates of COX-2 and VEGF-C in Ⅲ and Ⅳ stages of breast cancer were higher than those ofⅠand Ⅱ stages(P< 0.05).There was higher expression in the positive group of axillary lymphnode metastasis than that in the negtive group(P< 0.05).However

there were no correlations with ages

tumor size

ER and PR

etc.The expression rate of VEGF-C in the COX-2-positive group was higher than that in the negtive group

which were 76.2% vs 43.6%

respectively(P< 0.05).The expression of COX-2 and VEGF-C in breast cancer showed a positive correlation(r=0.579

P < 0.05) Conclusions: In breast cancer

The expression of COX-2 is significantly associated with clinic stage and axillary lymph node metastasis

and COX-2 could promote tumor cells to secrate VEGF-C and then accelerate lymphatic metastasis.

关键词

乳腺肿瘤环氧化酶-2VEGF-C淋巴转移

Keywords

Breast cancerCOX-2VEGF-CLymphatic metastasis

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