The study of the hypothalamic-pituitary-adrenal axis fuction in type 2 diabetes mellitus patients

ZHANG Rushuang; et al

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The study of the hypothalamic-pituitary-adrenal axis fuction in type 2 diabetes mellitus patients

更新时间：2024-01-17

- The study of the hypothalamic-pituitary-adrenal axis fuction in type 2 diabetes mellitus patients
- Journal of Chongqing Medical University Issue 8, Pages: 802-804(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌科
  2. 重庆医科大学附属第一医院内分泌科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R587.1
- Published：2007，
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[1]章汝霜,李启富,欧杨,李卫平,程庆丰,马仕坤,青华.2型糖尿病患者的下丘脑-垂体-肾上腺轴功能研究[J].重庆医科大学学报,2007(08):802-804.

ZHANG Rushuang, et al. The study of the hypothalamic-pituitary-adrenal axis fuction in type 2 diabetes mellitus patients. [J]. Journal of Chongqing Medical University (8):802-804(2007)
[1]章汝霜,李启富,欧杨,李卫平,程庆丰,马仕坤,青华.2型糖尿病患者的下丘脑-垂体-肾上腺轴功能研究[J].重庆医科大学学报,2007(08):802-804. DOI：

ZHANG Rushuang, et al. The study of the hypothalamic-pituitary-adrenal axis fuction in type 2 diabetes mellitus patients. [J]. Journal of Chongqing Medical University (8):802-804(2007) DOI：

摘要

目的:探讨2型糖尿病患者下丘脑-垂体-肾上腺（HPA）轴的功能改变。方法:比较正常对照组、IGR组（糖耐量减低和（或）空腹血糖受损）和2型糖尿病组的一般临床特征、早晨皮质醇浓度（唾液和血）及清晨唾液皮质醇升高值（MSCR）。结果:1)2型糖尿病组MSCR低于正常对照组

差异有统计学意义（P<0.05）。2)晨8时血浆皮质醇各组间差异均有统计学意义（P<0.01）

表现为IGR组最高

其次为2型糖尿病组。3)多元逐步回归分析提示年龄和HOMA-IR对MSCR有影响。结论:2型糖尿病患者存在HPA轴调节功能的紊乱

表现为MSCR低于正常人而晨8时血浆皮质醇高于正常人。

Abstract

Objective:To investigate the function of the hypothalamic-pituitary-adrenal(HPA)axis in type 2 diabetic patients.Methods:Subjects were divided into three groups:control group(normal glucose)

IGR group(IGT and/or IFG)and T2DM group.General clinical characteristics

morning cortisol concentrations(saliva and plasma)and MSCR(morning salivary cortisol rise)of the three groups were compared.Results:1)MSCR in the T2DM group was significantly lower than that in the control group(P<0.05);2)there were significant differences in plasma cortisol at 8 am.among the three groups(P<0.01)

with the highest level in the IGR and the next in the T2DM;3)stepwise regression analysis indicated age and HOMA-IR had significant associations with MSCR.Conclusion:MSCR is lower and plasma cortisol at 8 am is higher in T2DM patients than that in the normal group

which suggests T2DM patients have altered regulation of the HPA axis.

关键词

2型糖尿病下丘脑-垂体-肾上腺轴皮质醇唾液

Keywords

type 2 diabetes mellitusHypothalamic-pituitary-adrenal axisCortisolSaliva.

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