Investigation of protective role of Shenfu injection in ischemia-reperfusion injury of transplanted livers in rats

ZHANG Yi-bin; et al

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Investigation of protective role of Shenfu injection in ischemia-reperfusion injury of transplanted livers in rats

更新时间：2024-01-17

- Investigation of protective role of Shenfu injection in ischemia-reperfusion injury of transplanted livers in rats
- Journal of Chongqing Medical University Issue 4, Pages: 428-431(2008)
- 作者机构：
  
  1. 重庆医科大学附属第二医院肝胆外科
  2. 重庆医科大学附属第二医院肝胆外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285
- Published：2008，
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[1]张义彬,涂兵,龚建平,刘长安,陈蓁臻,郝荣涛.参附注射液对大鼠移植肝脏缺血再灌注损伤的保护作用[J].重庆医科大学学报,2008(04):428-431+445.

ZHANG Yi-bin, et al. Investigation of protective role of Shenfu injection in ischemia-reperfusion injury of transplanted livers in rats. [J]. Journal of Chongqing Medical University (4):428-431(2008)
[1]张义彬,涂兵,龚建平,刘长安,陈蓁臻,郝荣涛.参附注射液对大鼠移植肝脏缺血再灌注损伤的保护作用[J].重庆医科大学学报,2008(04):428-431+445. DOI：

ZHANG Yi-bin, et al. Investigation of protective role of Shenfu injection in ischemia-reperfusion injury of transplanted livers in rats. [J]. Journal of Chongqing Medical University (4):428-431(2008) DOI：

摘要

目的:研究参附注射液（Shenfu injection

SF）对大鼠移植肝脏在缺血再灌注损伤中的保护作用及其具体机制。方法:选用体重200～230g的雄性SD大鼠48只

随机分为对照组和SF组

进行肝脏移植。分别于肝移植完成后2、4、6h测定大鼠的胆汁分泌量

血清丙氨酸转移酶（ALT）和肿瘤坏死因子-α（TNF-α）水平

肝脏组织中核因子（NF-κB）的表达

以及肝脏组织的形态学观察（光镜、电镜）。结果:在各个时间点

SF组的胆汁分泌量明显高于对照组（P<0.05）

ALT、TNF-α含量明显低于对照组（P<0.05）

肝脏组织中NF-κB的表达较对照组明显减弱（P<0.05）。光镜和电镜下

SF组各时间点肝组织的损伤均较对照组明显减轻。结论:SF能明显减轻移植后肝脏结构和功能上的破坏

提高机体耐受缺血再灌注损伤的能力。

Abstract

Objective:To investigate the protective role of Shenfu injection(SF) in ischemia-reperfusion injury of transplanted livers in rats.Methods:48 male SD rats

weighted 200~230g

were selected and divided into control group and SF group at random.All of them were performed liver transplantation.2h

4h and 6h after the transplantation

they were analyzed for level of biliation

serum alanine aminotransferase

tumor necrosis factor-α(TNF-α)

NF-κB expression in hepatic tissue and the morphological observation of hepatic tissue under light/electron microscope.Results:At each phase

biliation in SF group was significantly higher than in control group(P<0.05);serum levels of ALT and TNF-α

NF-κB expression in hepatic tissue of SF group were significantly lower than in control group(P<0.05).At each phase

hepatic injury in SF group was significantly lighter than in control group under light/electron microscope.Conclusion:Shenfu injection can significantly palliate the injury of liver structure and function after liver transplantation

and enhance the tolerance of organism to ischemia-reperfusion injury.

关键词

参附注射液肝脏移植缺血再灌注损伤

Keywords

SF injectionLiver transplantationischemia-reperfusion injury

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