Clinic study of fresh amniotic membrane transplantation for ocular surface reconstruction

NIE Xin; et al

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Clinic study of fresh amniotic membrane transplantation for ocular surface reconstruction

更新时间：2024-01-17

- Clinic study of fresh amniotic membrane transplantation for ocular surface reconstruction
- Journal of Chongqing Medical University Issue 2, Pages: 231-233(2008)
- 作者机构：
  
  1. 重庆市第三人民医院眼科
  2. 重庆市第三人民医院眼科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：
  CLC： R779.6
- Published：2008，
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[1]聂昕,谯雁彬,郑延川.新鲜羊膜移植重建急性烧伤眼表的临床研究[J].重庆医科大学学报,2008(02):231-233.

NIE Xin, et al. Clinic study of fresh amniotic membrane transplantation for ocular surface reconstruction. [J]. Journal of Chongqing Medical University (2):231-233(2008)
[1]聂昕,谯雁彬,郑延川.新鲜羊膜移植重建急性烧伤眼表的临床研究[J].重庆医科大学学报,2008(02):231-233. DOI：

NIE Xin, et al. Clinic study of fresh amniotic membrane transplantation for ocular surface reconstruction. [J]. Journal of Chongqing Medical University (2):231-233(2008) DOI：

摘要

目的:探讨新鲜羊膜移植重建急性眼表烧伤眼表的可行性

并评价其疗效。方法:近2年我院就诊的急性眼表烧伤病例（20例24只眼）

施行新鲜羊膜移植手术治疗。患者术后随访12～26个月

平均（15±2）月。观察视力、角膜上皮愈合、角膜透明度、角膜新生血管和羊膜的转归。结果:羊膜移植后眼表迅速稳定

眼表面迅即并维持上皮化

无排斥

继发感染。20例中19例23眼在治疗后14～28d

羊膜基本溶解或吸收

角膜上皮完全愈合

1例1眼手术后12d发生角膜自融性基质溃疡

再次用药物治疗效果不佳

立行板层角膜移植术。新鲜羊膜移植术后的视力基本保留了眼前指数。结论:新鲜羊膜的移植可以减轻角膜急性烧伤期的炎症反应

阻止眼表的进行性溃烂和融解

加速眼表的稳定;同时减少角膜新生血管的形成

并在相当长的时间内将其局限在角膜周边部

从而为后续的角膜复明手术打下良好的基础。但对于严重化学烧伤患者

羊膜移植术的疗效是有限的。

Abstract

Objective:To explore the possibility of fresh amniotic membrane transplantation for reconstruction of ocular surface with acute burn and evaluate the effect.Method:20 cases(24 eyes)due to acute burn of ocular surface were performed fresh amniotic membrane transplantation.All patients were followed up for 12 months to 26 months

the mean follow-up was(15±2)months.Visual acuity

epithelial healing

corneal transparency

corneal neovascularization and transplanted amniotic membrane were observed.Results:After fresh amniotic membrane transplantation

ocular surface was soon stable

immune rejection and secondary infection didn’t occur.In 19 of 20 cases(23 eyes) the amniotic membrane autolyzed or disappeared with epithelized corneal surface at 14 to 28 days after operation.In one case(one eye) autolyzed corneal ulcer occurred at 12 days after operation.After another medication treatment was invalid

lamellar keratoplasty was performed.In other cases with AMT visual acuity keeps CF/5cm.Conclusion:Fresh amniotic membrane transplantation can lighten corneal inflammation in acute course of burn

can prevent ocular surface from ulcer and deliquescion

can fasten the stabilization and reduce corneal neovascularization

which provide a good basis for the following keratoplasty.With regard to severe eye burn

the effect of AMT is limited.

关键词

羊膜移植眼烧伤外科学

Keywords

Amniotic membranetransplantationEye burnSurgery

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210002,南京

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