Study of the PHB/PEO polymer combined with nerve growth factorin sciatic nerve injury

CHEN Yu; et al

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Study of the PHB/PEO polymer combined with nerve growth factorin sciatic nerve injury

更新时间：2024-01-17

- Study of the PHB/PEO polymer combined with nerve growth factorin sciatic nerve injury
- Journal of Chongqing Medical University Issue 2, Pages: 189-193(2008)
- 作者机构：
  
  1. 重庆市第九人民医院骨科
  2. 重庆市第九人民医院骨科,重庆,400700
- 作者简介：
- 基金信息：
- DOI：
  CLC： R651.3
- Published：2008，
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[1]陈渝,王大勇,王祖贵,翁政.PHB/PEO共聚物复合神经生长因子治疗坐骨神经损伤研究[J].重庆医科大学学报,2008(02):189-193.

CHEN Yu, et al. Study of the PHB/PEO polymer combined with nerve growth factorin sciatic nerve injury. [J]. Journal of Chongqing Medical University (2):189-193(2008)
[1]陈渝,王大勇,王祖贵,翁政.PHB/PEO共聚物复合神经生长因子治疗坐骨神经损伤研究[J].重庆医科大学学报,2008(02):189-193. DOI：

CHEN Yu, et al. Study of the PHB/PEO polymer combined with nerve growth factorin sciatic nerve injury. [J]. Journal of Chongqing Medical University (2):189-193(2008) DOI：

摘要

目的:研究PHB/PEO共聚物复合神经生长因子在周围神经缺损修复中的作用。方法:SD雄性大鼠分别进行自体神经移植、免疫抑制下的异体神经移植、PHB/PEO导管复合应用神经生长因子桥接缺损及PHB/PEO神经导管移植。采用坐骨神经功能指数检测和神经电生理测定进行神经功能测试。神经纤维计数和电镜观察研究神经解剖结构。结果:PHB/PEO导管复合神经生长因子组坐骨神经功能指数、神经传导速度和神经纤维计数与自体神经移植组相比无差异

显著优于异体神经移植组和PHB/PEO神经导管移植组;组织学和电镜检测显示PHB/PEO导管复合神经生长因子组神经纤维和髓鞘再生与自体神经移植组相相似

而显著优于其余2组。结论:在坐骨神经损伤修复中PHB/PEO导管复合应用神经生长因子神经修复效果与自体神经移植相似

而显著优于异体神经移植和PHB/PEO神经导管移植。

Abstract

Objective:To investigate the effect of PHB/PEO polymer combined with nerve growth factor in the peripheral nerve injury.Method:The male SD rats were treated with autogentic neural transplantation

xenogenic neural transplantation under the immunosuppression

transplantation of PHB/PEO polymer combined with nerve growth factor and PHB/PEO guidance transplantation

respectively.The nerve function and the nerve anatomic structure were evaluated by the sciatic function index(SFI)

nerval electrophysiology test

nerve fiber number and electron microscope.Result:The SFI

nerve conduction velocity

nerve fiber number and the regeneration of nerve fiber and myeline sheath of the PHB/PEO polymer combined with nerve growth factor group is similar to the autogentic neural transplantation group

and is better than the xenogenic neural transplantation group and PHB/PEO guidance group significantly.Conclusion:The effect of PHB/PEO polymer combined with nerve growth factor is similar to the autogentic neural transplantation

and is better than the xenogenic neural transplantation and PHB/PEO guidance significantly in the repair of sciatic nerve injury.

关键词

PHB/PEO共聚物周围神经损伤

Keywords

PHB/PEO polymerPeripheral nerveinjury

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