Expression of PTEN in endometrial carcinoma and its clinical significance

ZHOU Qin; et al

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Expression of PTEN in endometrial carcinoma and its clinical significance

更新时间：2024-01-17

- Expression of PTEN in endometrial carcinoma and its clinical significance
- Journal of Chongqing Medical University Issue 2, Pages: 186-188(2008)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科
  2. 重庆医科大学附属第一医院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.33
- Published：2008，
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[1]周勤,刘睿倩.PTEN在子宫内膜样腺癌中的表达及其临床意义[J].重庆医科大学学报,2008(02):186-188.

ZHOU Qin, et al. Expression of PTEN in endometrial carcinoma and its clinical significance. [J]. Journal of Chongqing Medical University (2):186-188(2008)
[1]周勤,刘睿倩.PTEN在子宫内膜样腺癌中的表达及其临床意义[J].重庆医科大学学报,2008(02):186-188. DOI：

ZHOU Qin, et al. Expression of PTEN in endometrial carcinoma and its clinical significance. [J]. Journal of Chongqing Medical University (2):186-188(2008) DOI：

摘要

目的:了解不同病理指标下抑癌基因PTEN（Phoshatase and tensin homology deleted on chromosome ten

PTEN）在子宫内膜样腺癌中的表达

探讨其与子宫内膜样腺癌的关系及其临床意义。方法:运用免疫组织化学方法测定PTEN在40例子宫内膜样腺癌、10例非典型增生子宫内膜和10例正常子宫内膜中的表达。结果:子宫内膜样腺癌标本中PTEN阳性染色率为55.00%

正常子宫内膜标本中PTEN阳性染色率为100.00%。但子宫内膜样腺癌中PTEN的表达与临床分期、肌层侵润深度、组织学分级及有无淋巴结转移等无明显相关性。结论:PTEN在子宫内膜样腺癌中有明显丢失现象

其在子宫内膜样腺癌早期发病中有着重要作用。

Abstract

Objectives:To study the expression of PTEN in endometrial carcinoma under different pathological factors and to discuss its relationshipwith the occurrence of endometrial carcinoma and the clinical significance.Methods:The expressions of PTEN in 40 cases of endometrial carcinoma

10 cases of atypical hyperplasia and 10 cases of normal endometria were examined by immunohistochemical method.Result:The positive staining rate of PTEN in endometrial carcinoma was 55.00%

and that in normal endometria was 100.00%.There was no obvious correlation between the expression of PTEN in endometrial carcinoma and different pathological factors such as clinical staging

depth of myometrial invasion and lymph node metastasis.Conclusion:The expression lack of PTEN exists in endometrial carcinoma

and PTEN has an important role in the occurrence of endometrial carcinoma.

关键词

PTEN子宫内膜样腺癌免疫组织化学

Keywords

PTENEndometrial carcinomaImmunohistochemical method

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