The clinical significance of the detection of cell surface marker and chromosome in leukemia

ZHAO Lin; et al

您当前的位置：

首页 >

文章列表页 >

The clinical significance of the detection of cell surface marker and chromosome in leukemia

更新时间：2024-01-17

- The clinical significance of the detection of cell surface marker and chromosome in leukemia
- Journal of Chongqing Medical University Issue 7, Pages: 885-887(2008)
- 作者机构：
  
  1. 重庆医科大学
  2. 重庆医科大学附属第二医院血液科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R733.7
- Published：2008，
扫描看全文
[1]赵琳,娄世锋.白血病的细胞表面标志及染色体检查的临床意义[J].重庆医科大学学报,2008(07):885-887.

ZHAO Lin, et al. The clinical significance of the detection of cell surface marker and chromosome in leukemia. [J]. Journal of Chongqing Medical University (7):885-887(2008)
[1]赵琳,娄世锋.白血病的细胞表面标志及染色体检查的临床意义[J].重庆医科大学学报,2008(07):885-887. DOI：

ZHAO Lin, et al. The clinical significance of the detection of cell surface marker and chromosome in leukemia. [J]. Journal of Chongqing Medical University (7):885-887(2008) DOI：

摘要

目的:探讨细胞表面标志及染色体检查对白血病的诊断、治疗、预后临床意义。方法:对初诊为急慢性白血病的22例患者进行骨髓细胞形态学、免疫学及细胞遗传学检测。按照FAB标准进行形态学分型

运用流式细胞仪、单克隆抗体（Monoclonal antibodies

McAb）检测细胞表面分化抗原（Clust of differentiation

CD）及其它细胞表面标志。采用短期培养法制备染色体标本

G显带技术作核型分析。结果:22例患者经形态学和免疫学联合诊断

急性淋巴细胞白血病（Acute lymphocyticleukemia

ALL）8例

其中伴有髓系抗原表达的ALL（Acute lymphocytic leukemia exhibiting myeloid lineage-associated antigens

My+ALL）2例

急性髓细胞白血病（Acute meylocytic leukemia

AML）9例

慢性淋巴细胞白血病（Chronic lymphocytic leukemia

CLL）3例

急性未分化型白血病（Acute undifferentiated leukemia

AUL）2例。成功制备的17例染色体标本中检出异常核型11例

检出率为64.7%

其中

2例具有染色体复杂畸形。接受化疗的12例患者中

除上述具有染色体复杂畸形的2例未缓解（Non-remission

NR）外

其余10例均完全缓解（Complete remission

CR）

CR率83.3%。结论:有针对性地运用细胞表面标志及染色体检查可在有限的条件下提高白血病的分型准确性

为白血病的个体化治疗和预后评估提供重要的信息。

Abstract

Objective:To investigate the clinical significance of the detection of cell surface marker and chromosome in diagnosis

treatment and prognosis of leukemia. Methods:Morphologic typing and immunophenotyping were carried out in 22 untreated patients with leukemia respectively with FAB criteria and monoclonal antibodies(McAb) which were used to label cell surface marker. Chromosomal specimens were prepared by 48-hour culture method. Chromosome was analysed by G-banding technique. Results:All the 22 cases were diagnosed as leukemia by combined detection of morphology and immunology. Among them there were 8 acute lymphocytic leukemia(ALL) in which 2 cases expressed myeloid lineage-associated antigens(My+ ALL)

9 acute meylocytic leukemia(AML) and 3 chronic lymphocytic leukemia(CLL). In addition

2 cases were diagnosed as acute undifferentiated leukemia(AUL). Chromosomal karyotype analysis was carried out in 17 cases

among which chromosomal abnormalities were found in 11 cases in which 2 cases with complex chromosomal deformity had non-remission(NR). With the exception of the 2 cases aforementioned

others had complete remission(CR). Conclusion:The proper detection of cell surface marker and chromosome on limited condition is helpful for the diagnosis of leukemia

which would provide an experimental evidence for personalized treatment and prognosis.

关键词

白血病细胞表面标志染色体

Keywords

leukemiaCell surface markerChromosome

references

Views

105

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Factors affecting the quality of life in children with leukemia and the relevant research progress at home and abroad

Effect of artesunate on autophagy of leukemic K562 cells and its mechanism

A DIRECT METHOD TO OBTAIN CHROMOSOME METAPHASE FROM HUMAN CHORIONIC VILLI

A COMPARISON OF SEVERAL LABORATORY METHODS IN THE DIAGNOSIS OF OVARIAN MALIGNANCIES

THE ANALYSIS OF SCE,Ag-NOR ANDAg-AA FOR THE BALANCED TRANSLOCATION CARRIERS

Related Author

Shi Lin

Mo Lin

He Yun

Liu Yang

Wang Zijuan

Zhang Ping

Yang Guicun

Chen Hongxia

Related Institution

the Third Surgical Ward,the Children’s Hospital,Chongqing Medical University

Special Needs Outpatient,the Children’s Hospital,Chongqing Medical University

Department of Hematology,the Children’s Hospital,Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,China International Science andTechnology Cooperation Base of Child Development and Critical Disorders,Chongqing Key Laboratory of Pediatrics

重庆医学院妇产科遗传室研究生

重庆医学院第一医院妇产科

⁰