Reversal effect of tetrandrine on multidrug resistance of the KBV200 cell line

YE Lin; et al

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Reversal effect of tetrandrine on multidrug resistance of the KBV200 cell line

更新时间：2024-01-17

- Reversal effect of tetrandrine on multidrug resistance of the KBV200 cell line
- Journal of Chongqing Medical University Issue 8, Pages: 967-969(2008)
- 作者机构：
  
  重庆医科大学附属第一医院耳鼻咽喉科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.6
- Published：2008，
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[1]叶琳,陈鸿雁.粉防己碱对喉癌耐药细胞株KBV200耐药逆转作用的研究[J].重庆医科大学学报,2008(08):967-969.

YE Lin, et al. Reversal effect of tetrandrine on multidrug resistance of the KBV200 cell line. [J]. Journal of Chongqing Medical University (8):967-969(2008)
[1]叶琳,陈鸿雁.粉防己碱对喉癌耐药细胞株KBV200耐药逆转作用的研究[J].重庆医科大学学报,2008(08):967-969. DOI：

YE Lin, et al. Reversal effect of tetrandrine on multidrug resistance of the KBV200 cell line. [J]. Journal of Chongqing Medical University (8):967-969(2008) DOI：

摘要

目的:研究天然有效成分粉防己碱（Tetrandrine

TET）对喉癌耐药细胞株KBV200的耐药逆转作用。方法:本研究以喉癌耐药细胞株KBV200为研究对象

采用粉防己碱逆转KBV200对常用抗肿瘤药物阿霉素的多药耐药作用

以经典逆转剂维拉帕米（Verapamil

VRP）为对照组

用四甲基偶氮唑蓝（MTT）法测定其对实验细胞的增殖抑制率。结果:低毒剂量的粉防己碱能逆转实验细胞株对阿霉素的多药耐药（Multidrug resistance

MDR）作用

逆转指数为22.96;维拉帕米逆转指数为9.31。结论:低毒浓度的天然药物粉防己碱能逆转喉癌耐药细胞株KBV200对阿霉素的耐药作用

其逆转效果优于经典逆转剂维拉帕米。

Abstract

Objective:To study the reversal effect of tetrandrine on multidrug resistance of KBV200 cell line in order to provide experimental data for clinical individual chemotherapy.Methods:MTT reduction assay was used to investgate the inhibition of Adriamycin on KBV200cell line

and the reversal effects of Tetrandrine and Verapamil on the cell line.Results:Verapamil and Tetrandrine had the reveral effects on the cell line

and the reversal indexes of Tetrandrine and Veramil were 22.96 and 9.31

respectively.Conclusion:KBV200 cell line was multidrug resistance to Adriamycin but Tetrandrine had reversal effects on its multidrug resistance.

关键词

粉防己碱维拉帕米KBV200细胞系多药耐药

Keywords

TetrandrineVerapamilKBV200 cell linemultidrug resistance

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