Effects of penehyclidine pretreatmeat on endotoxin-induced cerebral edema in rats

TU Zhen-zhen; et al

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Effects of penehyclidine pretreatmeat on endotoxin-induced cerebral edema in rats

更新时间：2024-01-17

- Effects of penehyclidine pretreatmeat on endotoxin-induced cerebral edema in rats
- Journal of Chongqing Medical University Issue 8, Pages: 963-966(2008)
- 作者机构：
  
  重庆医科大学附属第一医院麻醉科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R741
- Published：2008，
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[1]涂真真,高进,陈萍.长托宁预先给药对大鼠感染性脑水肿的影响[J].重庆医科大学学报,2008(08):963-966.

TU Zhen-zhen, et al. Effects of penehyclidine pretreatmeat on endotoxin-induced cerebral edema in rats. [J]. Journal of Chongqing Medical University (8):963-966(2008)
[1]涂真真,高进,陈萍.长托宁预先给药对大鼠感染性脑水肿的影响[J].重庆医科大学学报,2008(08):963-966. DOI：

TU Zhen-zhen, et al. Effects of penehyclidine pretreatmeat on endotoxin-induced cerebral edema in rats. [J]. Journal of Chongqing Medical University (8):963-966(2008) DOI：

摘要

目的:探讨长托宁（Penehyclidinehydrochloride

PHCD）对感染性脑水肿保护作用。方法:雄性S-D大鼠105只

200～220g

随机分为5组（n=21只）:对照组（C组）、水肿组（L组）、长托宁低、中、高剂量组（DL组0.05mg/kg、DM组0.15mg/kg和DH组0.45mg/kg）。向颈内动脉注射脂多糖（Lipopolysaccharide

LPS）150μg（0.15ml）建立大鼠感染性脑水肿模型。C组和L组腹腔注射生理盐水1ml

10min后向左颈内动脉注入无菌生理盐水0.15ml或LPS0.15ml;DL组、DM组DH组在注射LPS10min前分别腹腔给予0.05mg/kg、0.15mg/kg、0.45mg/kg长托宁。每组分别在手术后4h、6h和12h随机处死7只大鼠

每个时间点的5只用于测定脑组织含水量变化和光镜观察

其余2只电镜观察脑组织病理形态改变。结果:与C组相比

L组、DL组、DM组和DH组各时间点脑含水量增加（P<0.05）;与L组比较

DL组脑含水量改变不明显（P>0.05）

DM组和DH组脑含水量明显减少（P<0.05）。DM组和DH组病理学损伤较L组轻。结论:中高剂量长托宁预先给药可明显减轻脑水肿

改善血管内皮和神经元的损伤

对感染性脑水肿有治疗作用。

Abstract

Objective:To investigate the effects of Penehyclidinehydrochloride(PHCD) on endotoxin-induced cerebral edema.Methods:one handred and five S-D male rats(200～220g)were randomly divided into 5 groups(n=21):groupC control;groupL LPS;group DL

DM and DH received intraperitoneal PHCD 0.05

0.15 or 0.45mg/kg 10min before lipopolysaccharide(LPS) administration.Cerebral edema was induced by internal carotid arterial LPS 150μg.Seven animals each group were decapitated at 4、6 and 12h after operation and their brains were immediately removed for determination of water content of brain and microscopic examination.Results:Administration of LPS caused severe brain damage and significantly increased water content of the brain.The LPS-induced changes were mitigated by pretreatment with different doses of PHCD in groupDM and DH

but there was no significant difference between the two groups.Conclusion:Pretreatment with PHCD can attenuate LPS-induced cerebral edema.

关键词

长托宁感染脑水肿

Keywords

Penehyclidinehydrochlorideinfectioncerebral edema

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