Study on the relationship between polymorphism of PTPN22 and Graves’disease of Han nationality in Chongqing area

ZHENG Rui-zhi; et al

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Study on the relationship between polymorphism of PTPN22 and Graves’disease of Han nationality in Chongqing area

更新时间：2024-01-17

- Study on the relationship between polymorphism of PTPN22 and Graves’disease of Han nationality in Chongqing area
- Journal of Chongqing Medical University Issue 1, Pages: 22-24(2008)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌科
  2. 重庆医科大学附属第一医院内分泌科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R581.1
- Published：2008，
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[1]郑瑞芝,张素华,李蓉,汪志红,汪茂荣,万小莉,梁松.重庆地区汉族人PTPN22基因多态性与Graves病的关联研究[J].重庆医科大学学报,2008(01):22-24+28.

ZHENG Rui-zhi, et al. Study on the relationship between polymorphism of PTPN22 and Graves’disease of Han nationality in Chongqing area. [J]. Journal of Chongqing Medical University (1):22-24(2008)
[1]郑瑞芝,张素华,李蓉,汪志红,汪茂荣,万小莉,梁松.重庆地区汉族人PTPN22基因多态性与Graves病的关联研究[J].重庆医科大学学报,2008(01):22-24+28. DOI：

ZHENG Rui-zhi, et al. Study on the relationship between polymorphism of PTPN22 and Graves’disease of Han nationality in Chongqing area. [J]. Journal of Chongqing Medical University (1):22-24(2008) DOI：

摘要

目的:探讨重庆地区汉族人Graves病（GD）与蛋白酪氨酸磷酸酶非受体型22（PTPN22）基因外显子14 C1858T多态性的相关性。方法:运用PCR-RFLP技术分析283例GD患者和218例正常人PTPN22基因1858位点基因型

计算并比较两组基因型和等位基因频率。结果:PTPN22基因1858位点CC、CT和TT 3种基因型分布频率在GD组和正常组分别为97.2%、2.8%、0和97.7%、2.3%、0（χ2分别为0.139和0.002

P值分别为0.71和0.96）。其基因型和等位基因频率两组相比无统计学意义

未检出纯合子TT基因型

极少T等位基因。结论:PTPN22基因外显子14 C1858T多态性与重庆地区汉族人群GD的发生无相关性。

Abstract

Objective:To investigate the relationship between the polymorphism of PTPN22 gene exon14 C1858T and Graves’ disease(GD)in Han Group in Chongqing area.Methods:The PTPN22 gene C1858T alleles were typed by polymerase chain reaction based restriction fragment length polymorphism(PCR-RFLP)method in 283 GD patients and 218 normal subjects.The comparisons of genotype and allele frequencies were made between GD patients and normal group.Results:The frequencies of CC、CT and TT genotype in GD patients and normal group were 97.2%

2.8%

0% respectively

Their χ2 were 0.139 and 0.002 respectively

and p were 0.71 and 0.96 respectively.There was no significant difference of the genotypes and allele frequencies at position-1858 of PTPN22 in GD patients compared with those of normal group

and there was no TT genotype and a few T alleles.Conclusion:There is no correlation between the polymorphism of PTPN22 gene exon14 C1858T and GD patients in Han nationality of Chongqing.

关键词

Graves病蛋白酪氨酸磷酸酶非受体型22多态性

Keywords

Graves’ diseaseProtein tyrosine phosphatase non-receptor22polymorphism

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