Reserch on expression of CXCR4 in non small cell lung cancer cells

LI Xing; et al

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Reserch on expression of CXCR4 in non small cell lung cancer cells

更新时间：2024-01-17

- Reserch on expression of CXCR4 in non small cell lung cancer cells
- Journal of Chongqing Medical University Issue 4, Pages: 407-410(2008)
- 作者机构：
  
  1. 重庆医科大学附属第一医院胸心外科
  2. 重庆医科大学附属第一医院胸心外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  CLC： R734.2
- Published：2008，
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[1]李醒,温剑虎.CXCR4在非小细胞肺癌中的表达及意义[J].重庆医科大学学报,2008(04):407-410+449.

LI Xing, et al. Reserch on expression of CXCR4 in non small cell lung cancer cells. [J]. Journal of Chongqing Medical University (4):407-410(2008)
[1]李醒,温剑虎.CXCR4在非小细胞肺癌中的表达及意义[J].重庆医科大学学报,2008(04):407-410+449. DOI：

LI Xing, et al. Reserch on expression of CXCR4 in non small cell lung cancer cells. [J]. Journal of Chongqing Medical University (4):407-410(2008) DOI：

摘要

目的:探讨非小细胞肺癌（Non small cell lung cancer

NSCLC）中CXC类趋化因子受体4（Chemokine CXC motifreceptor 4

CXCR4）表达的意义

尤其是其表达在局部淋巴结转移中的作用。方法:未做治疗的41例NSCLC肿瘤原发灶、其中25例转移淋巴结和20例正常肺组织按SABC免疫组化法观察CXCR4的表达。结果:NSCLC原发灶中肿瘤细胞CXCR4表达阳性率为92.68%

高于正常肺组织细胞CXCR4表达阳性率10%（P<0.001）。不同临床特征NSCLC原发灶中肿瘤细胞CXCR4表达没有差异（P>0.05）。CXCR4表达强度与淋巴结转移也没有相关性（P>0.05）。肿瘤细胞在淋巴结转移灶中CXCR4表达阳性率96%

表达强度低于原发灶内（P<0.05）。结论:（1）不同组织学类型的NSCLC可能有共同的来源（。2）CXCR4高表达在NSCLC局部淋巴结转移中可能仅决定转移的靶向。

Abstract

Objective:To explore the expression of CXCR4 in non small cell lung cancer(NSCLC)

and further to explore the meaning of CXCR4

especially the role of CXCR4 in regional lymph nodes metastasis in NSCLC.Methods:SABC immunohistochemical staining was used to observe the expression of CXCR4.The specimens were 41 cases of primary tumor tissues of NSCLC

25 cases of regional metastasized lymph nodes

and 20 cases of normal lung tissues.Results:The positive rate of the expression of CXCR4 was 92.68% in primary tumor cells

and was higher than that in normal lung cells(P<0.001)

which was only 10%.There was no significant difference of CXCR4 expression in primary tumor cells with different clinicopathological characteristics(P>0.05).There was no significant correlation between the CXCR4 expression and the regional lymph nodes metastasis occurring(P>0.05).The positive expression rate of CXCR4 was 96% in cancer cells in regional metastasized lymph nodes.And its expression was lower than that in primary tumors(P<0.05).Conclusions:(1)NSCLCs of different histological types possibly have mutual origins.(2)CXCR4 probably only plays an role in inducing target metastasis of cancer cells to regional lymph nodes.

关键词

非小细胞肺癌CXC类趋化因子受体4淋巴结转移免疫组化

Keywords

Non small cell lung cancer(NSCLC)Chemokine CXC motif receptor 4lymph nodemetastasisimmunohistochemistry

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