Expression of aquaporin1 in human amniotic membrane and its significance

ZHAO Ze-yan; et al

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Expression of aquaporin1 in human amniotic membrane and its significance

更新时间：2024-01-17

- Expression of aquaporin1 in human amniotic membrane and its significance
- Journal of Chongqing Medical University Issue 2, Pages: 163-165(2008)
- 作者机构：
  
  1. 山西省运城市中心医院妇产科
  2. 重庆医科大学附属第一医院妇产科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R714
- Published：2008，
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[1]赵泽燕,漆洪波,张华,张建华.水通道蛋白1在人羊膜上皮细胞的表达及意义[J].重庆医科大学学报,2008(02):163-165.

ZHAO Ze-yan, et al. Expression of aquaporin1 in human amniotic membrane and its significance. [J]. Journal of Chongqing Medical University (2):163-165(2008)
[1]赵泽燕,漆洪波,张华,张建华.水通道蛋白1在人羊膜上皮细胞的表达及意义[J].重庆医科大学学报,2008(02):163-165. DOI：

ZHAO Ze-yan, et al. Expression of aquaporin1 in human amniotic membrane and its significance. [J]. Journal of Chongqing Medical University (2):163-165(2008) DOI：

摘要

目的:探讨水通道蛋白1（Aquaporin1

AQP1）在人羊膜中的表达、定位及意义。方法:应用免疫组织化学方法检测12例正常足月妊娠产妇、11例羊水过少及9例羊水过多者足月妊娠产妇的羊膜组织中AQP1蛋白的表达。结果:AQP1在羊膜组织立方上皮细胞中有阳性表达

且主要位于细胞浆中

而在成纤维细胞中仅有微弱表达。羊水过少及过多患者与正常产妇的羊膜组织AQP1蛋白面积积分光密度值比较差异均有显著性（P<0.05）。结论:人羊膜组织表达AQP1蛋白

其在羊水的液体转运中可能起着重要作用

为羊水的水转运机制研究提供了分子生物学基础

并且为羊水量异常的治疗提供了新的思路。

Abstract

Objective:To investigate the expression

location and significance of aquaporin1(AQP1) in the tissue of amniotic membrane.Methods:Immunohistochemical method was used to examine the expression of aquaporin1 in the tissue of amniotic membrane of 12 normal full-term pregnant women

11 full-term pregnamt woman with oligohydramnios and 9 with polyhydramnios.Result:Aquaporin1 was expressed in cuboidal epithelial cells of amniotic membrane

and mainly in cytoplasm.There was but a little expression of aquaporin1 in fibroblast of amniotic membrane tissue.There was statistically significant difference of the AQP1 expression between oligohydramnios

polyhydramnios and normal full-term pregnancy women integrative optical density in amniotic membrane tissue

respectively(P<0.05).Conclusion:AQP1 is expressed in cytoplasm of amniotic membrane tissue of human

and it may play a critical role in the process of water-transference.This study provides a molecular biological basis for the study the on molecular mechanism of amniotic fluid transport

and a new thinking for treating abnormal capacity for amniotic fluid.

关键词

水通道蛋白1（AQP1）羊膜

Keywords

Aquaporin1Amniotic membrane

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