Research on the relationship between ALDH2 and CYP2E1 gene polymorphism and alcoholic liver disease in Han people

LENG Ai-min; et el

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Research on the relationship between ALDH2 and CYP2E1 gene polymorphism and alcoholic liver disease in Han people

更新时间：2024-01-17

- Research on the relationship between ALDH2 and CYP2E1 gene polymorphism and alcoholic liver disease in Han people
- Journal of Chongqing Medical University Issue 9, Pages: 1108-1110(2008)
- 作者机构：
  
  湖南省长沙市中南大学湘雅医院消化科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R575
- Published：2008，
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[1]冷爱民,王德强,袁伟建.汉族人群酒精性肝病ALDH2和CYP2E1基因多态性研究[J].重庆医科大学学报,2008(09):1108-1110.

LENG Ai-min, et el. Research on the relationship between ALDH2 and CYP2E1 gene polymorphism and alcoholic liver disease in Han people. [J]. Journal of Chongqing Medical University (9):1108-1110(2008)
[1]冷爱民,王德强,袁伟建.汉族人群酒精性肝病ALDH2和CYP2E1基因多态性研究[J].重庆医科大学学报,2008(09):1108-1110. DOI：

LENG Ai-min, et el. Research on the relationship between ALDH2 and CYP2E1 gene polymorphism and alcoholic liver disease in Han people. [J]. Journal of Chongqing Medical University (9):1108-1110(2008) DOI：

摘要

目的:研究乙醛脱氢酶（Aldehyde dehydrogenase

ALDH）和细胞色素P4502E1（Cytochrome P4502E1

CYP2E1）基因多态性与汉族人群酒精性肝病（Alcoholic liver disease

ALD）的关系。方法:应用聚合酶链反应-限制性片断长度多态性（PCR-RFLP）方法检测汉族人群中对照组（45例）、ALD组（48例）、嗜酒无肝病组（38例）和非酒精性肝病组（42例）中ALDH和CYP2E1各基因型及等位基因的频率并进行比较。结果:ALDH2*1、ALDH2*22种等位基因在对照组与ALD组和非酒精性肝病组与ALD组之间的分布差异有显著性（P<0.05）

在嗜酒组和ALD组中以ALDH2*1/1基因型为主。CYP2E1的c1、c2两种等位基因在ALD组与其他3组比较分布均有显著性差异（P<0.05）。结论:ALDH与CYP2E1基因多态性与ALD的发生关系密切。等位基因ALDH2*2可能是汉族人群中嗜酒和ALD的负性危险因素。B（c1/c2）型基因型在ALD发生中起着重要的作用

c2等位基因与ALD的发生有关。

Abstract

Objective:To explore the relationship between genetic polymorphism of ALDH2 and CYP2E1 and alcoholic liver disease(ALD) in Han people. Methods:PCR-RFLP was used to detect the frequencies of gene types and allele of ALDH and CYP2E1 in health control group(45 cases)

ALD group(48 cases)

alcohol dependent group(38 cases) and non-ALD(NALD) group(42 cases)

and the frequencies were compared. Results:The difference of the frequencies of ALDH2*1 and ALDH2*2 had statistic significance between health control group and ALD group

and between in ALD group and NALD group(P<0.05). ALDH2*1 was the main gene type for alcohol dependent group and ALD group. The frequency of CYP2E1 c1 and c2 had statistically significant difference from the orther three groups(P<0.05). Conclusion:The gene polymorphism of ALDH2 has close relationship to the pathogenesis of ALD. ALDH*2 allele may be a negative risk factor for alcoholism and ALD in Chinese Han people. The gene polymorphism of CYP2E1 has close relationship to the pathogenesis of ALD. The genotype of B(c1/c2)plays a important role in the development of ALD and c2 allele is relevant to the pathogenesis of ALD.

关键词

酒精性肝病乙醛脱氢酶细胞色素P4502E1基因多态性

Keywords

Alcoholic liver diseaseAldehyde dehydrogenaseCytochrome P4502E1gene polymorphism

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