Espression and significance of MMP-14 and MMP-2,TIMP-2 in gastric cancer

JIA Ying-dong; et al

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Espression and significance of MMP-14 and MMP-2,TIMP-2 in gastric cancer

更新时间：2024-01-17

- Espression and significance of MMP-14 and MMP-2,TIMP-2 in gastric cancer
- Journal of Chongqing Medical University Issue 7, Pages: 799-802(2008)
- 作者机构：
  
  重庆医科大学附属第一医院普外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.2
- Published：2008，
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[1]贾映东,王子卫.MMP-14、MMP-2、TIMP-2在胃癌组织中表达及意义[J].重庆医科大学学报,2008(07):799-802+810.

JIA Ying-dong, et al. Espression and significance of MMP-14 and MMP-2,TIMP-2 in gastric cancer. [J]. Journal of Chongqing Medical University (7):799-802(2008)
[1]贾映东,王子卫.MMP-14、MMP-2、TIMP-2在胃癌组织中表达及意义[J].重庆医科大学学报,2008(07):799-802+810. DOI：

JIA Ying-dong, et al. Espression and significance of MMP-14 and MMP-2,TIMP-2 in gastric cancer. [J]. Journal of Chongqing Medical University (7):799-802(2008) DOI：

摘要

目的:探讨基质金属蛋白酶（Metalloproteinase

MMP）-14、-2、基质金属蛋白酶组织抑制因子（Tissue inhibitor ofmetalloproteinase

TIMP）-2在胃癌、癌旁组织及胃溃疡中的表达情况及相互关系。方法:用免疫组织化学方法（SP法）检测30例胃癌手术病人及20例胃镜活检胃溃疡病人中MMP-14、MMP-2、TIMP-2的表达。结果:（1）胃癌组织中

TIMP-2、MMP-2及MMP-14表达阳性率分别为43.3%、76.7%、53.3%

胃癌癌旁组织中分别为56.7%、46.7%和40%

胃溃疡组织中分别为70%、45%和30%。（2）在胃癌中

TIMP-2的阳性表达与癌旁组织及胃溃疡组织比较有统计学差异（P<0.01）

MMP-2阳性表达与溃疡组织之间比较有统计学差异（P<0.05）。（3）在癌组织中

MMP-2、MMP-14和TIMP-2表达均与浆膜是否受侵、淋巴结有无转移和TNM临床分期密切相关（P<0.05）。（4）双变量相关分析

在胃癌组织中

MMP-14和MMP-2阳性表达呈正相关（rs=0.447

P>0.05）

而TIMP-2阳性表达与前两者均呈显著负相关（rs=-1.0

P<0.01）。结论:（1）MMP-1在胃癌中高表达。（2）MMP-14和MMP-2阳性表达呈正相关

是胃癌的侵袭转移性因素之一。（3）MMP-14表达上调的同时激活了更多的MMP-2

增加了胃癌向周围组织侵袭转移的能力。

Abstract

Objective:To detect the expression of MMP-14

MMP-2 and TIMP-2 in gastric ulcer tissues

gastric cancer and tissues around gastric cancer. Methods:The expression of MMP-14

MMP-2

and TIMP-2 were detected by S-P immunohistochemistry in gastric ulcer tissues

gastric cancer tissues and around tissues from operated patients of gastric cancer (n=30) and gastric ulcer patients(n=20)who were diagnosed by stomach lens. Results:(1) The expression rates of TIMP-2

MMP-2 and MMP-14was 43.3%

76.7% and 53.3% respectively in gastric cancer tissues and 56.7%

46.7% and 40%in tissues around it

but 70%

45% and 30% in gastric ulcer tissues. (2) The expression of TIMP-2 in gastric cancer was lower than that in tissues or that in gastric ulcer tissues(P<0.01).The expression of MMP-2 in gastric cancer was higher then that of gastric ulcer(P<0.05).(3) The expression of MMP-2

MMP-14 and TIMP-2 in gastric cancer tissues were closely correlated to the serosa invaded

lymph node metastasis and TNM stages(P<0.05). (4) There was positive correlation between the expression of MMP-2 and MMP-14 in gastric cancer(rs=0.447

P>0.05).The expression of TIMP-2 was negatively correlated with the expression of MMP-2 or MMP-14(rs=-1.0

P<0.01)in gastric cancer. Conclusions:(1)The MMP-14 in gastric cancer is over expressed.(2)MMP -14 was one of invading and metastasis factors in gastric cancer and could judge prognosis of it. (3)The high expression of MMP-14 and MMP-2 showed that increased expression of MMP-14 resulted in more MMP-2 activation and increased ability of invading and metastasis in the tissues around gastric cancer. (4)TIMP-2 plays an important role in resisting MMP-14 in gastric cancer and gastric ulcer tissues.

关键词

胃癌MMP-14MMP-2TIMP-2

Keywords

gastric cancerMMP-14MMP-2TIMP-2

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