The expressions of ICAM-1 and VCAM-1 in HIE neonatal rabbits

LIN Jing-cang; et al

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The expressions of ICAM-1 and VCAM-1 in HIE neonatal rabbits

更新时间：2024-01-17

- The expressions of ICAM-1 and VCAM-1 in HIE neonatal rabbits
- Journal of Chongqing Medical University Vol. 33, Issue 12, Pages: 1499-1501(2008)
- 作者机构：
  
  泉州医学高等专科学校组织胚胎学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R722.151
- Published：2008，
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[1]林迳苍,朱世泽,杜翠琼,许相洋,黄煌.ICAM-1及VCAM-1等在HIE新生兔的表达[J].重庆医科大学学报,2008,33(12):1499-1501.

LIN Jing-cang, et al. The expressions of ICAM-1 and VCAM-1 in HIE neonatal rabbits. [J]. Journal of Chongqing Medical University 33(12):1499-1501(2008)
[1]林迳苍,朱世泽,杜翠琼,许相洋,黄煌.ICAM-1及VCAM-1等在HIE新生兔的表达[J].重庆医科大学学报,2008,33(12):1499-1501. DOI：

LIN Jing-cang, et al. The expressions of ICAM-1 and VCAM-1 in HIE neonatal rabbits. [J]. Journal of Chongqing Medical University 33(12):1499-1501(2008) DOI：

摘要

目的:探索慢性宫内缺氧对新生兔中性粒细胞与细胞粘附分子表达的影响。方法:取孕中晚期新西兰兔15只

随机分为对照组、缺氧组以及中药干预缺氧组;对比3组新生兔中性粒细胞细胞粘附分子CD11b/CD18、脑组织细胞间粘附分子1（Intercellularadhesion moleacule-1

ICAM-1）以及血管内皮细胞粘附分子1（Vascular cell adhension moleules1

VCAM-1）等的表达与变化。结果:与对照组比较

缺氧组和中药干预缺氧组的CD11b/CD18、ICAM-1以及VCAM-1表达均显著增强;虽然缺氧组和中药干预缺氧组的表达存在差异

但无统计学意义。结论:提示缺氧缺血后中性粒细胞趋化作用增强并且脑血管内皮细胞粘附增加而导致的脑组织细胞的损伤

参与HIE的病理生理过程。

Abstract

Objective:Searching after the effects of the expressions the neonatal rabbits with chronic intrauterine anoxemia give to neutrophil and conglutinated molecule.Method:Choosing 15 Zelanian rabbits that have been in afternoon pregnancy

we divide them into three stochastic contratest groups by chance:the control group

the anoxic group and the group interfered with Chinese traditional medicine.Then

we contrast the expressions and changes of these groups with CD11b/CD18

ICAM-1 and VCAM-1.Results:Contrasting the CD11b/CD18

ICAM-1 and VCAM-1 of the anoxic group and the group interfered with Chinese traditional medicine with chinese traditional medicine with the control group

we have found their expressions all more remarkably strengthened;There is some difference in expression between the anoxic group and the group interfered with Chinese traditional medicine

but it has little statistical significance.Conclusion:In this article

there occurs the mention:the chemotaxis of neutrophil has been strengthened and the endotheliocytosis of cerebrovascular has been conglutinated under anoxemia;as a result

the chemotaxis and endotheliocytosis have marred the brain cell tissue and participated in whole pathological and physiological process.

关键词

慢性宫内缺氧新生兔细胞粘附分子CD11b/CD18脑组织细胞间粘附分子1血管内皮细胞粘附分子1

Keywords

The intranterine anoxemiaNeonatal rabbitsConglutinated moleculeCD11b/CD18Intercellular adhesion moleacule-1(ICAM-1)Vascular cell adhension moleules 1(VCAM-1)

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梁栋

LIN Jing-cang

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Related Institution

Department of Surgery,Bishan People Hospital

重庆市第八人民医院

Department of Hisology and Embrgdgy,Quanzhou Medical College

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