A study on the enhancement of therapeutic efficacy of HIFU by magnetic nano-particles

LI Quan-yi; et al

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A study on the enhancement of therapeutic efficacy of HIFU by magnetic nano-particles

更新时间：2024-01-17

- A study on the enhancement of therapeutic efficacy of HIFU by magnetic nano-particles
- Journal of Chongqing Medical University Vol. 34, Issue 1, Pages: 63-65(2009)
- 作者机构：
  
  重庆医科大学生物医学工程系重庆市-科技部共建超声医学工程重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R454
- Published：2009，
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[1]李全义,李发琪,秦艳.纳米磁性颗粒增强HIFU治疗效率的研究[J].重庆医科大学学报,2009,34(01):63-65.

LI Quan-yi, et al. A study on the enhancement of therapeutic efficacy of HIFU by magnetic nano-particles. [J]. Journal of Chongqing Medical University 34(1):63-65(2009)
[1]李全义,李发琪,秦艳.纳米磁性颗粒增强HIFU治疗效率的研究[J].重庆医科大学学报,2009,34(01):63-65. DOI：

LI Quan-yi, et al. A study on the enhancement of therapeutic efficacy of HIFU by magnetic nano-particles. [J]. Journal of Chongqing Medical University 34(1):63-65(2009) DOI：

摘要

目的:探讨纳米磁性颗粒（Magnetic nano-particles

MNP）对高强度聚焦超声（High intensity focused ultrasound

HIFU）损伤效率的影响。方法:将直径为80～90nm的磁性颗粒0.05g和直径为200～300nm的磁性颗粒0.05g和0.10g分别均匀分布在270ml蛋白凝胶体模中

用同一高强度聚焦超声剂量辐照

结束后测量损伤线最大剖面的长和宽。结果:含有0.05g直径为80～90nm的磁性颗粒的蛋白凝胶体模与对照组相比未见增效

而200～300nm的磁性颗粒与对照组相比损伤面积增大3倍多（P<0.01）。结论:直径为200～300nm的磁性颗粒能够改变蛋白凝胶体模的声学环境

从而提高高强度聚焦超声对其损伤的效率。

Abstract

Objective:To investigate the effects of magnetic nano-particles on the therapeutics efficacy of high intensity focused ultrasound(HIFU).Methods:The magnetic nano-particles with diameter of 80～90 nm and 200～300 nm were distributed into the egg white phantom respectively.At the same HIFU exposure dose

the length and width of the maximum cross section of the lesions were measured.Results:The results showed that the magnetic nano-particles with diameter of 200～300 nm can enhance the therapeutic efficacy of HIFU

and the areas of lesions were about 2 times larger than those of control group(P<0.01)

But the group of 80～90 nm almost had no difference from control group(P>0.01).Conclusion:The magnetic nano-particles with diameter of 200～300 nm can change the acoustics environment of egg white phantom and enhance the therapeutic efficacy of HIFU.

关键词

纳米磁性颗粒高强度聚焦超声治疗效率

Keywords

Magnetic nano-particlesHigh intensity focused ultrasound(HIFU)Therapeutic efficiency

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重庆医科大学医学超声工程研究所

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