The expression and significance of CTGF,TGFβ3 and their receptors in fissure tissues of the patients with NSCLP

TIAN Xiao-fei; et al

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The expression and significance of CTGF,TGFβ3 and their receptors in fissure tissues of the patients with NSCLP

更新时间：2024-01-17

- The expression and significance of CTGF,TGFβ3 and their receptors in fissure tissues of the patients with NSCLP
- Journal of Chongqing Medical University Vol. 34, Issue 1, Pages: 55-58(2009)
- 作者机构：
  
  重庆医科大学儿童医院整形烧伤外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R782.2
- Published：2009，
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[1]田晓菲,金先庆,罗庆,邱林,傅跃先.CTGF、TGFβ3及其受体在唇腭裂裂缘组织中的表达及意义[J].重庆医科大学学报,2009,34(01):55-58.

TIAN Xiao-fei, et al. The expression and significance of CTGF,TGFβ3 and their receptors in fissure tissues of the patients with NSCLP. [J]. Journal of Chongqing Medical University 34(1):55-58(2009)
[1]田晓菲,金先庆,罗庆,邱林,傅跃先.CTGF、TGFβ3及其受体在唇腭裂裂缘组织中的表达及意义[J].重庆医科大学学报,2009,34(01):55-58. DOI：

TIAN Xiao-fei, et al. The expression and significance of CTGF,TGFβ3 and their receptors in fissure tissues of the patients with NSCLP. [J]. Journal of Chongqing Medical University 34(1):55-58(2009) DOI：

摘要

目的:探讨转化生化因子β3（Tansforminggrow facotrβ3

TGFβ3）、结缔组织生化因子（Connectire tissue growth factor

CT-GF）及其受体TGFβRⅡ、LRP6与非综合征性唇腭裂（Nonsyndromic cleft lip and/or cleft palate

NSCLP）发生的关系。方法:实验组标本40例

为NSCLP患儿裂缘皮肤、粘膜组织。对照组标本18例

为正常儿童的口唇部皮肤、粘膜组织。通过免疫组织化学SP法

检测TGFβ3、CTGF及其受体TGFβRⅡ、LRP6在实验组和对照组中的表达。结果:实验组CTGF的表达与正常对照组相比无显著性差异（P>0.05）;实验组CTGF受体LRP6的表达较正常对照组降低（P<0.01）;实验组TGFβ3的表达较正常对照组明显增高（P<0.01）;实验组TGFβ3受体TGFβRⅡ的表达与对照组无显著性差异（P>0.05）。结论:CTGF受体LRP6及TGFβ3的表达异常可能与NSCLP的发生有关。

Abstract

Objective:To explore the association of CTGF

TGFβ3 and their receptors(TGFβRⅡ、LRP6)with the generation of NSCLP.Methods:There were 40 samples in experimental group and 18 samples in control group.The expression of CTGF

TGFβ3 and their receptors(TGFβRⅡ、LRP6)in fissure tissues of the patients with NSCLP were measured by SP immunohistochemistry and analyzed.Results:There was no variability for the expression of CTGF between the experimental group and the control group(P>0.05)

but the expression of CTGF receptor(LRP6)decreased in experimental group

compared with that in control group(P<0.01).Significant increase in the expression of TGFβ3 was observed in the experimental group(P<0.01)

but there was no difference in the expression of TGFβ3 receptor(TGFβRⅡ)between the experimental group and the control group(P>0.05).Conclusion:CTGF receptor(LRP6)and TGFβ3 might have relationship with the generation of NSCLP

关键词

唇腭裂结缔组织生化因子转化生化因子β3免疫组织化学法

Keywords

Nonsyndromic cleft lip and/or cleft palateConnectire tissue growth factor(CTGF)Tansforming grow facotr β3(TGFβ3)Immunohistochemistry

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