Effect of sevoflurane of different concentrations on vecuronium muscle relaxation

LI Qi-ying; et al

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Effect of sevoflurane of different concentrations on vecuronium muscle relaxation

更新时间：2024-01-17

- Effect of sevoflurane of different concentrations on vecuronium muscle relaxation
- Journal of Chongqing Medical University Vol. 34, Issue 2, Pages: 249-250(2009)
- 作者机构：
  
  重庆医科大学附属第一医院麻醉科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R614
- Published：2009，
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[1]李琪英,闵苏.吸入不同浓度的七氟烷对维库溴铵肌松效应的影响[J].重庆医科大学学报,2009,34(02):249-250.

LI Qi-ying, et al. Effect of sevoflurane of different concentrations on vecuronium muscle relaxation. [J]. Journal of Chongqing Medical University 34(2):249-250(2009)
[1]李琪英,闵苏.吸入不同浓度的七氟烷对维库溴铵肌松效应的影响[J].重庆医科大学学报,2009,34(02):249-250. DOI：

LI Qi-ying, et al. Effect of sevoflurane of different concentrations on vecuronium muscle relaxation. [J]. Journal of Chongqing Medical University 34(2):249-250(2009) DOI：

摘要

目的:探讨吸入不同浓度的七氟烷对维库溴铵肌松效应的影响。方法:80例择期开腹手术患者随机分为4组:对照组（Ⅰ组）

吸入七氟烷1MAC（Ⅱ组）

1.5MAC（Ⅲ组）

2MAC（Ⅳ组）。比较不同MAC七氟烷对维库溴铵肌松效应的影响。分别记录各组注入维库溴铵后其抑制时间、T1恢复时间及恢复指数。结果:起效时间Ⅱ组与Ⅰ组相比较差异无统计学意义（P>0.05）

而Ⅲ组和Ⅳ组与Ⅰ组相比明显缩短（P<0.05）;T125%（注药结束到T1恢复到25%）、及Tl75%恢复时间及恢复指数上

Ⅲ组和Ⅳ组与Ⅰ组相比均有明显的延长（P<0.05）。结论:吸入1.5MAC以上七氟烷明显增强维库溴铵的肌松效应。延长维库溴铵的作用时间

Abstract

Objective:Approach effect of sevoflurane of different concentrations on vecuronium muscle relaxation.Methods:Eighty pa-tients scheduled for abdorminal surgery were divided randomly into four groups:comparison group(group 1)

inhalating sevoflurane with 1 MAC(group 2)

1.5 MAC(group 3)or 2 MAC(group 4).The effect of sevoflurane with different MAC on vecuronium muscle relaxation were observed.Inhibiting time

T1 recovery time and recovery index in four groups after vecuronium injection were recorded.Results:There was no significant difference in inhibiting time between group 1 and group 2(P>0.05)

and that in group 3 or group 4 was obviously shorter than in group 1(P<0.05).The number of T125%

T175%and recovery index in gourp 3 and gourp 4 was notably bigger than that in group 1(P<0.05).Conclusion:Inhalating over 1.5 MAC sevoflurane strengthens vecuronium muscle relaxation and prolongs its effecting time.

关键词

七氟烷维库溴铵神经肌肉阻滞

Keywords

sevofluranevecuroniumNerve-muscle blockade

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Related Institution

Department of Anesthesiology,the First Affiliated Hospital,Chongqing Medical University

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重庆医科大学附属口腔医院颌面外科

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