Effects of angiogenin on apoptosis cells in the brain of rats with reversible-ischemic injury

ZHAO Ya-feng; et al

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Effects of angiogenin on apoptosis cells in the brain of rats with reversible-ischemic injury

更新时间：2024-01-17

- Effects of angiogenin on apoptosis cells in the brain of rats with reversible-ischemic injury
- Journal of Chongqing Medical University Issue S1, Pages: 20-22(2008)
- 作者机构：
  
  北京大学人民医院神经内科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R743.3
- Published：2008，
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[1]赵亚锋,郭淮莲,程敏.血管生长素对大鼠脑缺血再灌注细胞凋亡的影响[J].重庆医科大学学报,2008(S1):20-22.

ZHAO Ya-feng, et al. Effects of angiogenin on apoptosis cells in the brain of rats with reversible-ischemic injury. [J]. Journal of Chongqing Medical University (S1):20-22(2008)
[1]赵亚锋,郭淮莲,程敏.血管生长素对大鼠脑缺血再灌注细胞凋亡的影响[J].重庆医科大学学报,2008(S1):20-22. DOI：

ZHAO Ya-feng, et al. Effects of angiogenin on apoptosis cells in the brain of rats with reversible-ischemic injury. [J]. Journal of Chongqing Medical University (S1):20-22(2008) DOI：

摘要

目的:观察腹腔注射重组人血管生长素（Recombinant human angiogenin

rhANG）对脑缺血再灌注大鼠缺血半暗带区凋亡细胞数目的影响。方法:大鼠大脑中动脉栓塞2h再灌注72h制作脑缺血再灌注模型。大鼠分为假手术组、脑缺血对照组、rhANG腹腔注射组（15ng/100g体重）。采用凋亡细胞DNA原位末端标记法（TUNEL）检测凋亡细胞。结果:rhANG腹腔注射组与脑缺血对照组相比缺血半暗带区凋亡细胞数目差异无显著性（P>0.05）。脑缺血对照组及rhANG腹腔注射组大鼠脑内缺血侧凋亡细胞数目明显多于非缺血侧。结论:腹腔注射rhANG（15ng/100g体重）对脑缺血再灌注大鼠缺血半暗带区凋亡细胞数目无显著影响。

Abstract

Objective:The purpose is to observe the change of the number of apoptosis cell in the reversible-ischemia rat brain after the intraperitoneal injection of rhANG. Methods:With the use of a reversible(middle cerebral artery occlusion (MCAO))m odel in rats

apoptosis cells were assessed by(terminal deoxynucleotedyl transferase(TdT))-mediated dUTP-biotin nick end labe ling(TUNEL) histochemical methods in sham

brain ischemia control and rhANG intraperitoneal injection groups.Results:There was no significant difference in the number of the apoptosis cell in the penumbra zone in the ischemic brain between the rhANG intraperitoneal injection group and the brain ischemia control group.The number of apoptosis cell in the ischemic lateral brain was increased significantly compared with the non-ischemia lateral in the brain ischemia control group and the rhANG intraperitoneal injection group. Conclusion:There was no significant difference in the number of the apoptosis cell in the penu mbra zone in the ischemic rat brain after the intraperitoneal injection of rhANG(15ng/100g)compared with the control group.

关键词

血管生长素脑缺血再灌注大鼠凋亡

Keywords

Angiogenin (ANG)Brain reversible-ischemiaratapoptosis

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