Relationship between coronary heart disease and polymorphisms of endothelial nitric oxide synthase gene G894T in Han Nationality

PENG Jin-yu; et al

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Relationship between coronary heart disease and polymorphisms of endothelial nitric oxide synthase gene G894T in Han Nationality

更新时间：2024-01-17

- Relationship between coronary heart disease and polymorphisms of endothelial nitric oxide synthase gene G894T in Han Nationality
- Journal of Chongqing Medical University Vol. 34, Issue 1, Pages: 20-23(2009)
- 作者机构：
  
  1. 湖南省疾病预防控制中心性艾科
  2. 中南大学湘雅三医院检验科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.4
- Published：2009，
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[1]彭瑾瑜,彭怀燕,聂新民.汉族人内皮型一氧化氮合酶基因G894T多态性与冠心病关系的研究[J].重庆医科大学学报,2009,34(01):20-23.

PENG Jin-yu, et al. Relationship between coronary heart disease and polymorphisms of endothelial nitric oxide synthase gene G894T in Han Nationality. [J]. Journal of Chongqing Medical University 34(1):20-23(2009)
[1]彭瑾瑜,彭怀燕,聂新民.汉族人内皮型一氧化氮合酶基因G894T多态性与冠心病关系的研究[J].重庆医科大学学报,2009,34(01):20-23. DOI：

PENG Jin-yu, et al. Relationship between coronary heart disease and polymorphisms of endothelial nitric oxide synthase gene G894T in Han Nationality. [J]. Journal of Chongqing Medical University 34(1):20-23(2009) DOI：

摘要

目的:研究汉族人内皮型一氧化氮合酶（Endothelial nitric oxidesynthase

eNOS）基因G894T多态性与冠心病（Coronaryheart disease

CAD）的关系。方法:采用聚合酶链反应限制性片断长度多态性（Polymerase chain reaction-restricted fragments length polymorphism

PCR-RFLP）技术检测了103例CAD患者、104例对照组eNOS基因G894T多态性的基因型

分析了其对CAD的影响。结果:CAD组和对照组eNOS基因G894T多态性的等位基因频率有显著性差异（P=0.029）

但是基因型分布在两组间的差异无统计学意义。Logistic回归分析确定高血压病、糖尿病及吸烟史为CAD发生的独立危险因素

T等位基因不是其发生的独立危险因素。结论:CAD组的eNOS基因G894T突变频率高于对照组

T等位基因可能与CAD的发生有一定的关联。

Abstract

Objective:To explore the relationship between polymorphism of endothelial nitric oxide synthase(eNOS)gene G894T and coronary heart disease(CAD)in Han Nationlity.Methods:Polymerase chain reaction-restricted fragments length polymorphism(PCR-RFLP)was used to determine the genotype of the eNOS gene G894T in 103 patients with CAD and 104 controls.Results:There was significant difference in frequencies of allele in G894T polymorphism of eNOS gene between CAD and control groups(P=0.029)

but there was no significant difference in genotype distribution between two groups.Logistic regression analysis revealed that hypertension

diabete mellitus and smoking history were independent risk factors for the incidence of CAD

but T allele was not.Conclusion:The frequency of eNOS gene G894T mutation in the CAD group is higher than that in the control group and T allele may be related to with the development of CAD.

关键词

内皮型一氧化氮合酶冠心病基因多态性基因型等位基因

Keywords

endothelial nitric oxide synthasecoronary heart diseasegene polymorphismgenotypeAllele

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重庆医科大学基础医学院生物教研室

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Department of Clinical Molecular Medicine of Children’s Hospital of Chongqing Medical University， National Clinical Research Center for Child Health and Disorders，Ministry of Education Key Laboratory of Child Development and Disorders，Chongqing Key Laboratory of Pediatrics

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