Effects of Trail combined with chenotherapeutics on proliferation and apoptosis of HNE-1 cell line

YU Xiao-yan; et al

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Effects of Trail combined with chenotherapeutics on proliferation and apoptosis of HNE-1 cell line

更新时间：2024-01-17

- Effects of Trail combined with chenotherapeutics on proliferation and apoptosis of HNE-1 cell line
- Journal of Chongqing Medical University Vol. 34, Issue 6, Pages: 709-711(2009)
- 作者机构：
  
  重庆医科大学附属第一医院耳鼻咽喉科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.63
- Published：2009，
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[1]余晓燕,邓碧,沈娜,叶琳,张潜英,陈鸿雁.化疗药物联合TRAIL对鼻咽癌细胞株增殖抑制的实验研究[J].重庆医科大学学报,2009,34(06):709-711.

YU Xiao-yan, et al. Effects of Trail combined with chenotherapeutics on proliferation and apoptosis of HNE-1 cell line. [J]. Journal of Chongqing Medical University 34(6):709-711(2009)
[1]余晓燕,邓碧,沈娜,叶琳,张潜英,陈鸿雁.化疗药物联合TRAIL对鼻咽癌细胞株增殖抑制的实验研究[J].重庆医科大学学报,2009,34(06):709-711. DOI：

YU Xiao-yan, et al. Effects of Trail combined with chenotherapeutics on proliferation and apoptosis of HNE-1 cell line. [J]. Journal of Chongqing Medical University 34(6):709-711(2009) DOI：

摘要

目的:探讨肿瘤坏死因子相关凋亡诱导配体（TNF related apoptosis indncing ligmard

TRAIL）联合化疗药物顺铂（Cisplatin

DDP）、5氟尿嘧啶（5-Fluorouracil

5-FU）作用于鼻咽癌HNE-1细胞株后对其细胞毒作用及凋亡影响的研究。方法:MTT法检测其增殖抑制率

FCM法检测细胞凋亡率。结果:TRAIL与DDP、5-FU联合作用于HNE-1细胞株时

其抑制率、凋亡率高于单独作用时的抑制率和凋亡率。结论:TRAIL与5-FU、DDP联合作用有协同抑制HNE-1细胞株增殖、诱导HNE-1细胞株凋亡的作用。

Abstract

Objective:To observe the effects of different concentrations of TRAIL and chemotherapeutic drugs(5-FU

DDP) on proliferation and apoptosis of HNE-1 cell lines

both singlely and jointly.Methods:MTT was used to detect the inhibition rate.FCM was used to detect the apoptosis rate of cell.Results:The inhibition rate and apoptosis rate of combination use of TRAIL and 5-FU

DDP were significantly increased

compared with those of single use of TRAIL.Conclusion:The inhibition of proliferation and apoptosis of HNE-1 cell line can be induced by TRAIL

and the effects were higher by TRAIL combined with 5-FU and DDP.

关键词

TRAILDDP5-FUHNE-1细胞株

Keywords

TRAILDDP5-FUHNE-1 cell line

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Related Author

SU Yan-xin

王立

YU Xiao-yan

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Related Institution

Department of Gastroemerology,the First Affiliated Hospital,Chongqing Medical University

重庆医科大学附属第一医院消化内科

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