Expression and implication of apoptosis related gene bcl-2,bad in human breast cancer

CHEN Jian-sheng; et al

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Expression and implication of apoptosis related gene bcl-2,bad in human breast cancer

更新时间：2024-01-17

- Expression and implication of apoptosis related gene bcl-2,bad in human breast cancer
- Journal of Chongqing Medical University Vol. 34, Issue 6, Pages: 702-705(2009)
- 作者机构：
  
  重庆医科大学附属第二医院普外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.9
- Published：2009，
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[1]陈建生,孙治君,于冰.凋亡相关基因bcl-2、bad在乳腺癌中的表达及意义[J].重庆医科大学学报,2009,34(06):702-705.

CHEN Jian-sheng, et al. Expression and implication of apoptosis related gene bcl-2,bad in human breast cancer. [J]. Journal of Chongqing Medical University 34(6):702-705(2009)
[1]陈建生,孙治君,于冰.凋亡相关基因bcl-2、bad在乳腺癌中的表达及意义[J].重庆医科大学学报,2009,34(06):702-705. DOI：

CHEN Jian-sheng, et al. Expression and implication of apoptosis related gene bcl-2,bad in human breast cancer. [J]. Journal of Chongqing Medical University 34(6):702-705(2009) DOI：

摘要

目的:探讨凋亡相关基因bcl-2、bad在乳腺癌组织中的表达及其与患者预后的关系。方法:采用免疫组化方法检测10例正常乳腺组织、10例乳腺纤维瘤组织、40例青年乳腺癌组织、40例老年乳腺癌组织中bcl-2、bad基因的表达

并检测80例乳腺癌组织中ER、PR的表达。结果:bcl-2表达随乳腺癌的组织学分级增加呈递减趋势（P<0.01）

青年乳腺癌患者bcl-2表达阳性率显著低于老年乳腺癌患者（P<0.05）

bcl-2表达阳性率与腋窝淋巴结转移呈负相关（P<0.05）

与ER、PR表达呈正相关（P<0.05）。bad表达随乳腺癌的组织学分级增加也呈递减趋势（P<0.05）

青年乳腺癌患者bad表达阳性率显著低于老年乳腺癌患者（P<0.05）

bad表达阳性率与腋窝淋巴结转移、ER、PR表达无明显相关（P>0.05）。结论:bcl-2、bad可以作为预测乳腺癌预后的因子。检测乳腺癌组织中bcl-2基因表达水平

特别是联合检测bcl-2、bad以及ER、PR的表达水平

有助于个体化判断乳腺癌患者的预后

并指导治疗。

Abstract

Objective:To evaluate the expression and significance of Bcl-2

Bad gene and its relationship with prognosis of breast cancer.Methods:Immunohistochemical technique was used to detect the expression of Bcl-2

Bad gene in 10 cases of normal breast tissue

10 breast fibroadenoma tissue

40 young human breast carcinoma tissue and 40 old human breast carcinoma tissue.The expression of ER and PR in 80 cases of human breast carcinoma tissue were also detected.Results:The expression of bcl-2

bad gene decreased in the development of breast cancer(P<0.01).The expressions of bcl-2

bad gene in young human breast carcinoma tissue were lower than that in old human breast carcinoma tissue(P<0.05).There was a positive correlation between the positive rate of bcl-2 and the positive rate of ER、PR(P<0.05).There was a negative correlation between the positive rate bcl-2 and histologic grade or the node metastasis(P<0.05).The expressions of bcl-2、bad gene in young human breast carcinoma tissue were lower than in old human breast carcinoma tissue(P<0.05).The expression of bad gene was not related to the expression of ER

histologic grade and the node metastasis(P>0.05).Conclusion:The expression of bcl-2 and bad can be used as predicted factors of breast cancer.Detection of the expression level of the bcl-2 protein

in particular the combined detection of the expressions of bcl-2 and bad as well as ER and PR is helpful in forecasting the prognosis of breast carcinoma and instructing the treatment.

关键词

乳腺癌bcl-2基因bad基因细胞凋亡

Keywords

breast cancerbcl-2badapoptosis

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