Expression of DDR1a in colon carcinoma cells and its relationship with matrix metalloproteinase 2,9

HE Miao; et al

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Expression of DDR1a in colon carcinoma cells and its relationship with matrix metalloproteinase 2,9

更新时间：2024-01-17

- Expression of DDR1a in colon carcinoma cells and its relationship with matrix metalloproteinase 2,9
- Journal of Chongqing Medical University Vol. 34, Issue 2, Pages: 161-163(2009)
- 作者机构：
  
  重庆医科大学附属第一医院胃肠外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.35
- Published：2009，
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[1]何苗,傅仲学.DDR1a在结肠癌细胞株中的表达及与基质金属蛋白酶2,9的关系[J].重庆医科大学学报,2009,34(02):161-163.

HE Miao, et al. Expression of DDR1a in colon carcinoma cells and its relationship with matrix metalloproteinase 2,9. [J]. Journal of Chongqing Medical University 34(2):161-163(2009)
[1]何苗,傅仲学.DDR1a在结肠癌细胞株中的表达及与基质金属蛋白酶2,9的关系[J].重庆医科大学学报,2009,34(02):161-163. DOI：

HE Miao, et al. Expression of DDR1a in colon carcinoma cells and its relationship with matrix metalloproteinase 2,9. [J]. Journal of Chongqing Medical University 34(2):161-163(2009) DOI：

摘要

目的:探讨结肠癌细胞中盘状结构域受体酪氨酸激酶1（Discoidin domain receptor tyrosine kinases1a

DDR1a）的表达和基质金属蛋白酶2（Matrix metalloproteinase 2

MMP2）、基质金属蛋白酶9（Matrix metalloproteinase9

MMP9）的活性及其相互的关系。方法:用Westernblot检测结肠癌细胞株和人正常结肠平滑肌细胞株中DDR1a表达

明胶酶谱法检测各细胞株中的MMP2

MMP9的活性。结果:侵袭能力强的结肠癌细胞LOVO中

DDR1a呈显著高表达（P<0.01）及MMP2、MMP9呈显著高活性（P<0.01）

此外在所测细胞中DDR1a表达与MMP2及MMP9活性呈显著正相关（P<0.05）。结论:本研究提示DDR1a可作为反映结肠癌细胞侵袭力生物学指标之一。

Abstract

Objective:To investigate the expression of DDR1a and the activities of MMP2

MMP9 in colon carcinoma cells and their mutual relations.Methods:The expression of DDR1a in colon carcinoma cell and human colon smooth muscle cell was detected by Western blot

the activities of MMP2

MMP9 were examined by gelatin zymography analysis.Results:The expression of DDR1a and the activities of MMP2

MMP9 in colon carcinoma cell(LOVO)which has stronger invasive behavior were significant higher(P<0.01).There was significant positive correlationship between the expression of DDR1a and the activities of MMP2

MMP9 in tested cells(P<0.05).Conclusion:DDR1a may act as one of biological indicators of the invasion in colon carcinoma cells.

关键词

盘状结构域受体酪氨酸激酶1a结肠癌细胞基质金属蛋白酶2基质金属蛋白酶9

Keywords

Discoidin domain receptor tyrosine kinases1aColon carcinoma cellsMatrix metalloproteinase 2Matrix metalloproteinase 9

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