Primary NK/T cell lymphoma of the testis:two cases report and review of the Iiterature

LI Dan; et al

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Primary NK/T cell lymphoma of the testis:two cases report and review of the Iiterature

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- Primary NK/T cell lymphoma of the testis:two cases report and review of the Iiterature
- Journal of Chongqing Medical University Vol. 34, Issue 8, Pages: 1123-1127(2009)
- 作者机构：
  
  重庆医科大学基础医学院病理学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.21
- Published：2009，
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[1]李丹,林晓,米粲.原发睾丸NK/T细胞淋巴瘤2例报告及文献复习[J].重庆医科大学学报,2009,34(08):1123-1127.

LI Dan, et al. Primary NK/T cell lymphoma of the testis:two cases report and review of the Iiterature. [J]. Journal of Chongqing Medical University 34(8):1123-1127(2009)
[1]李丹,林晓,米粲.原发睾丸NK/T细胞淋巴瘤2例报告及文献复习[J].重庆医科大学学报,2009,34(08):1123-1127. DOI：

LI Dan, et al. Primary NK/T cell lymphoma of the testis:two cases report and review of the Iiterature. [J]. Journal of Chongqing Medical University 34(8):1123-1127(2009) DOI：

摘要

目的:探讨原发睾丸NK/T细胞淋巴瘤的临床病理特征、诊断和预后。方法:通过光镜、免疫组化对2例原发睾丸NK/T细胞淋巴瘤进行临床病理观察及原位杂交检测EB病毒

并结合文献加以分析。结果:2例原发睾丸NK/T细胞淋巴瘤。形态学示例1肿瘤细胞中等偏小

例2肿瘤细胞呈小、中、大混合

均呈弥漫生长

核不规则、扭曲

破坏睾丸正常组织结构

可见血管壁浸润破坏血管

可见小灶性凝固性坏死。免疫组化:瘤细胞CD45、CD2、CD56、胞浆型CD3（CD3ε）、CD45RO和Granzyme B阳性表达

CD57、CD20、CD79a、CD30、CK、MPO、TdT、BCL-2和PLAP阴性。原位杂交50%肿瘤细胞EBER1/2阳性。结论:原发睾丸NK/T细胞淋巴瘤极罕见

临床经过呈高度侵袭性

预后差。免疫组化染色CD56、CD3ε、EBER和细胞毒性颗粒相关蛋白（如GranzymeB等）阳性对诊断和鉴别诊断有重要作用。

Abstract

Objective:To study the clinical and pathological features of primary NK/T cell lymphoma of testis and to investigate the effective diagnosis and treatment of this disease.Methods:The surgical specimens of two patients with primary NK/T cell lymphoma of the testis were observed by light microscopy

immunohistochemistry and examined by in situ hybridization for Epstein-Barr virus(EBV) RNA and the literature were reviewed.Results:The two patients respectively presented with bilateral and right-side painless testicular enlargement.The neoplastic cells were positive for CD45

CD2

CD56

cytoplasmic CD3(CD3ε)

CD45RO and Granzyme B

while the expressions of CD57

CD20

CD79a

CD30

MPO

TdT

BCL-2 and PLAP were negative.In addition

the EBV RNA was detected in the lymphoma by in situ hybridization.Conclusion:Primary NK/T cell lymphoma of the testis is a rare entity and progressed rapidly.The expression of CD56

CD3ε

cytotoxic granule associated ptoteins and EBV examination by in situ hybridization play an important role in diagnosis and differential diagnosis.

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淋巴瘤杀伤细胞自然T细胞睾丸EB病毒

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