Effect of Shuxuetong injection on the expressions of TGF-β<sub>1</sub> and Col-IV in renal tissues in diabetic rats

JIANG Wen-juan; et al

您当前的位置：

首页 >

文章列表页 >

Effect of Shuxuetong injection on the expressions of TGF-β₁ and Col-IV in renal tissues in diabetic rats

更新时间：2024-01-17

- Effect of Shuxuetong injection on the expressions of TGF-β₁ and Col-IV in renal tissues in diabetic rats
- Journal of Chongqing Medical University Vol. 34, Issue 11, Pages: 1514-1517(2009)
- 作者机构：
  
  重庆医科大学附属第二医院内分泌科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2009，
扫描看全文
[1]蒋文娟,郭瑞清,郭常辉,郑天鹏.疏血通注射液对糖尿病大鼠肾脏TGF-β_1及Col-Ⅳ表达的影响[J].重庆医科大学学报,2009,34(11):1514-1517.

JIANG Wen-juan, et al. Effect of Shuxuetong injection on the expressions of TGF-β₁ and Col-IV in renal tissues in diabetic rats. [J]. Journal of Chongqing Medical University 34(11):1514-1517(2009)
[1]蒋文娟,郭瑞清,郭常辉,郑天鹏.疏血通注射液对糖尿病大鼠肾脏TGF-β_1及Col-Ⅳ表达的影响[J].重庆医科大学学报,2009,34(11):1514-1517. DOI：

JIANG Wen-juan, et al. Effect of Shuxuetong injection on the expressions of TGF-β₁ and Col-IV in renal tissues in diabetic rats. [J]. Journal of Chongqing Medical University 34(11):1514-1517(2009) DOI：

摘要

目的:探讨疏血通注射液对实验性糖尿病大鼠尿蛋白和转化生长因子β1（Transforming growth factor β1

TGF-β1）、Ⅳ型胶原（Collegen type Ⅳ

Col-Ⅳ）表达的影响。方法:采用链脲佐菌素（Streptozotocin

STZ）制备早期糖尿病肾病（Diabetic nephropathy

DN）模型

随机分为正常对照组、DN未治疗组、疏血通治疗组、苯那普利对照组

8周后观察尿白蛋白排泄率（Urinary albumin excretion rate

UAER）、尿β2微球蛋白（β2-miro globulin

β2-MA）、肾脏肥大指数（KW/BW）的变化;免疫组化法检测肾组织TGF-β1、Col-IV的表达水平。结果:与DN未治疗组相比

疏血通组的UAER、尿β2-MA、KW/BW均下降（P<0.05或P<0.01）

肾组织TGF-β1、Col-Ⅳ表达下调（P<0.05）。结论:疏血通注射液对糖尿病大鼠具有肾脏保护作用

其机制可能与下调肾组织TGF-β1、Col-Ⅳ的表达有关。

Abstract

Objective:To investigate the effect of Shuxuetong injection on the urine protein excretion changes and expressions of transforming growth factor β(1TGF-β1)and collegen type Ⅳ(Col-Ⅳ)in renal tissues in diabetic rats.Methods:Diabetic nephropathy was induced by intraperitoneal injection of streptozotocin(STZ).Rats were randomly divided into control group

untreated DN group

Shuxuetong group and Benazepril group.Urinary albumin excretion rate(UAER)

β2-microglobulin(β2-MA)and KW/BW(kidney weight/body weigh)were determined 8 weeks later.The expressions of TGF-β1 and Col-Ⅳ in renal tissues were determined by using immunohistochemical methods.Results:After interference

compared with the untreated DN group

UAER

β2-MA

KW/BW in the Shuxuetong group were significantly down-regulated(P <0.05 or P <0.01);the expressions of TGF-β1 and Col-Ⅳ in renal tissues were significantly inhibited(P <0.05).Conclusion:Shuxuetong injection has a renoprotective effect on diabetic rats

which may be relate to the down-regulation of the expressions of TGF-β1 and Col-Ⅳ in renal tissues.

关键词

糖尿病肾病疏血通注射液转化生长因子-β1Ⅳ型胶原

Keywords

diabetic nephropathyShuxuetong injectionTransforming growth factorβ1Collegen typeⅣ

references

Views

104

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Carvacrol alleviates oxidative stress damage in rats with diabetic nephropathy via the SIRT1/FOXO1 pathway

Protection of sodium glucose cotransporter-2 inhibitors on diabetic nephropathy

Effects of HIF1α-KIM1 signaling pathway on renal interstitial fibrosis in diabetic nephropathy

URINARY N-ACETY1-β-D-GLUCOSAMIMDASE DETERMINATION FOR DETECTION OF DIABETIC NEPHROPATHY AT EARLYSTAGE

The relationship between epidermal growth factor and diabetic nephro-pathy in NIDDM patients

Related Author

Liu Xia

Wang Xia

Yang Bingqi

Ren Wei

Xia Jiajia

Hu Yumei

Dang Yong

Related Institution

Department of Obstetrics and Gynecology，Hebei Provincial Hospital of Traditional Chinese Medicine

河北省中医院导管室

Department of Endocrinology,The First Affiliated Hospital of Chongqing Medical University

The First Clinical Medical College of Nanchang University

Department of Nephrology,Anyang People’s Hospital Henananyang

⁰

Effect of Shuxuetong injection on the expressions of TGF-β1 and Col-IV in renal tissues in diabetic rats

DOI：

摘要

Abstract

关键词

Keywords

references

Effect of Shuxuetong injection on the expressions of TGF-β₁ and Col-IV in renal tissues in diabetic rats