Relationship between high density lipoprotein cholesterol and coronary heart disease

YAO Wu-wei; et al

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Relationship between high density lipoprotein cholesterol and coronary heart disease

更新时间：2024-01-17

- Relationship between high density lipoprotein cholesterol and coronary heart disease
- Journal of Chongqing Medical University Vol. 34, Issue 11, Pages: 1510-1513(2009)
- 作者机构：
  
  重庆医科大学附属第二医院老年病科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R541.4
- Published：2009，
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[1]姚武位,陈庆伟,柯大智.高密度脂蛋白胆固醇和冠心病的相关性研究[J].重庆医科大学学报,2009,34(11):1510-1513.

YAO Wu-wei, et al. Relationship between high density lipoprotein cholesterol and coronary heart disease. [J]. Journal of Chongqing Medical University 34(11):1510-1513(2009)
[1]姚武位,陈庆伟,柯大智.高密度脂蛋白胆固醇和冠心病的相关性研究[J].重庆医科大学学报,2009,34(11):1510-1513. DOI：

YAO Wu-wei, et al. Relationship between high density lipoprotein cholesterol and coronary heart disease. [J]. Journal of Chongqing Medical University 34(11):1510-1513(2009) DOI：

摘要

目的:探讨高密度脂蛋白胆固醇水平与冠心病的相关性。方法:选择427例经冠状动脉造影证实的冠心病患者作为病例组

并选择同期住院的冠脉造影结果阴性的306例非冠心病患者作为对照组

测定两组患者的血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、游离脂肪酸（FFA）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）、脂蛋白LP（a）等指标进行比较分析。结果:冠心病组与对照组比较

HDL-C水平显著降低（P<0.05）;在冠心病组中随着冠状动脉病变支数的增加

HDL-C逐渐下降（P<0.05）。多元Logistic回归分析

低HDL-C水平为冠心病的独立危险因素。结论:HDL-C与冠心病发生发展及冠脉病变程度呈显著负相关。TC/HDL-C可能对冠心病的诊断具有更好的预测价值。

Abstract

Objective:To investigate the relationship between high density lipoprotein cholesterol(HDL-C)and coronary heart disease(CHD).Methods:A total of 427 CHD patients diagnosed by coronary angiography were selected as cases

and 306 non-CHD patients admitted to the hospital in the same period were selected as controls.Serum total cholesterol(TC)

triglycerides(TG)

high density lipoprotein cholesterol(HDL-C)

low-density lipoprotein cholesterol(LDL-C)

apolipoproteinA1(ApoA1)

apolipoprotein B(ApoB)

lipoprotein(a)(LP(a))

and free fatty acids(FFA)were determined and analyzed.Results:The levels of HDL-C in CHD group were significantly lower than that in non-CHD group(P<0.05).In CHD group

HDL-C decreased gradually as the number of coronary artery disease branch increased(P<0.05).Logistic multiple regression analysis

showed low HDL-C level was an independent risk factor for coronary heart disease.Conclusion:HDL-C show significantly negative correlation to the incidence

development and severity of coronary heart disease.TC / HDL-C may have a better predictive value in coronary heart disease diagnosis.

关键词

高密度脂蛋白胆固醇冠心病

Keywords

HDL-Ccoronary heart disease

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Related Institution

Department of General Medicine，The Second Affiliated Hospital of Chongqing Medical University

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重庆医科大学临床学院心内科

Department of Cardiology,College of Clinical Medicine,Chongqing Medical University

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