The detection of ER,PR and DNA ploidy,p53 gene in colorectal cancer and its clinical value

LUO Qi; et al

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The detection of ER,PR and DNA ploidy,p53 gene in colorectal cancer and its clinical value

更新时间：2024-01-17

- The detection of ER,PR and DNA ploidy,p53 gene in colorectal cancer and its clinical value
- Journal of Chongqing Medical University Vol. 34, Issue 8, Pages: 1066-1069(2009)
- 作者机构：
  
  厦门大学附属中山医院福建医科大学厦门中山教学医院普外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.34
- Published：2009，
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[1]罗琪,张颂恩,张诗峰,卢毅卓.大肠癌ER、PR表达和DNA倍体、p53基因的检测及其临床意义[J].重庆医科大学学报,2009,34(08):1066-1069.

LUO Qi, et al. The detection of ER,PR and DNA ploidy,p53 gene in colorectal cancer and its clinical value. [J]. Journal of Chongqing Medical University 34(8):1066-1069(2009)
[1]罗琪,张颂恩,张诗峰,卢毅卓.大肠癌ER、PR表达和DNA倍体、p53基因的检测及其临床意义[J].重庆医科大学学报,2009,34(08):1066-1069. DOI：

LUO Qi, et al. The detection of ER,PR and DNA ploidy,p53 gene in colorectal cancer and its clinical value. [J]. Journal of Chongqing Medical University 34(8):1066-1069(2009) DOI：

摘要

目的:探讨大肠癌（Colorectal cancer）、雌激素受体（Estrogen receptor

ER）、孕激素受体（Progesterone receptor

PR）表达和DNA倍体、p53基因的检测结果与临床分类、预后评估的关系。方法:采用RBA法、免疫组织化学方法和流式细胞术对286例大肠癌标本分别进行ER、PR表达和p53基因检测及DNA倍体分析并结合患者的临床资料进行分析。结果:ER、PR表达和p53基因检测及DNA倍体分析与大肠癌患者预后均有明显相关

差异有极显著性意义（P<0.01）。DNA二倍体、p53基因表达越低其患者预后越好;ER、PR的表达越强说明肿瘤与激素依赖性越强

肿瘤的生物学行为较好。结论:大肠癌ER、PR表达和p53基因检测及DNA倍体分析有助于大肠癌患者的临床分类及预后评估。

Abstract

Objective:To study the clinical value of detecting estrogen receptor(ER)

progesterone receptor(PR) and p53 gene

DNA ploidy in colorectal cancer.Methods:Combined with clinical data

286 specimens of colorectal cancer were detected with ER

p53 gene and DNA ploidy analysis by radiobioassay(RBA)

immunohistochemistry and flow cytometry.Results:The expressions of ER

p53 gene and of DNA ploidy analysis correlated with the prognosis of colorectal cancer patient(P<0.01).The higher the expressions of ER

P53 gene and DNA ploidy analysis

the better the prognosis.Conclusion:The detection of ER

p53 gene and DNA ploidy analysis is useful for clinical classification and prognosis of colorectal cancer.

关键词

大肠癌雌激素受体孕激素受体p53DNA倍体

Keywords

colorectal cancerestrogen receptorprogesterone receptorp53DNA ploidy

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