Objective:To investigate the effects of Shenfu injection on cerebral oxygen balance and cerebral ischemia-reperfusion injury in patients undergoing valve replacement during cardiopulmonary bypass

in order to Explore its efficacy and find reasonable route of administration. Methods: 32 patients undergoing valve replacement

aged 25～54

with the heart function of 2～3 level

were randomly divided into four groups with eight in each. Patients in group E1 received SFI 1.5 ml/kg before blocking of the aorta;Patients in group E2 received SFI 1.5 ml/kg after opening of the aorta;Patients in group E3received SFI 0.75 ml/kg before blocking and after opening the aorta

too. Patients in group C received 0.9% NaCl. Blood samples were taken from internal jugular vein and arteria radialis after trachea cannula(T1)

10 min after CPB(T2)

cooling stability stage(T3)

recovery temperature to 33℃(T4)

the end of CPB(T5) and 1 hour after the end of CPB(T6)for blood gas analysis.Then

Plasma S100β protein concentration、MDA、Glu and the activity of SOD in jugular vein bulb were determined. Results: The CERO2

SjvO2 changes in Group E1

E2

E3 were stable

moreover

SjvO2 was significantly higher than that in group C (P <0.05).There were no difference in these three groups.In Group E1

E2

E3

the S100β plasma protein and MDA

Glu were lower than those in group C (P <0.05)

and at T6

these indicators were the lowest in E3(P <0.05); SOD activity significantly decreased at the start of CPB in group C(P <0.05)

however

there were no obvious change after administrotion SFI(P>0.05)

In group E3

SOD had the highest activity at T6(P <0.05). Conclusion:SFI maintain a heart valve replacement in patients with cerebral oxygen balance

reduce serum S100β protein

MDA and Glu content and enhance the activity of SOD

so it has effect on cerebral protection. Furthermore

the E3 group had the best effect.