Expreesion of AXL and its significance in human glioma and meningioma

WU Pei-tao; et al

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Expreesion of AXL and its significance in human glioma and meningioma

更新时间：2024-01-17

- Expreesion of AXL and its significance in human glioma and meningioma
- Journal of Chongqing Medical University Vol. 34, Issue 10, Pages: 1341-1344(2009)
- 作者机构：
  
  重庆医科大学附属第一医院神经外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R739.4
- Published：2009，
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[1]吴佩涛,谢延风,孙晓川.AXL在人脑胶质瘤及脑膜瘤中的表达及意义[J].重庆医科大学学报,2009,34(10):1341-1344.

WU Pei-tao, et al. Expreesion of AXL and its significance in human glioma and meningioma. [J]. Journal of Chongqing Medical University 34(10):1341-1344(2009)
[1]吴佩涛,谢延风,孙晓川.AXL在人脑胶质瘤及脑膜瘤中的表达及意义[J].重庆医科大学学报,2009,34(10):1341-1344. DOI：

WU Pei-tao, et al. Expreesion of AXL and its significance in human glioma and meningioma. [J]. Journal of Chongqing Medical University 34(10):1341-1344(2009) DOI：

摘要

目的:探讨AXL基因在颅内减压术切除组织、恶性胶质细胞瘤及脑膜瘤中的表达情况及其意义。方法:收集的31例人脑胶质细胞瘤标本

25例人脑脑膜瘤标本

12例颅内减压术切除组织标本。采用逆转录酶聚合酶链反应检测AXLmRNA的表达。结果:AXL在颅内减压术切除组织和脑膜瘤中表达呈阳性

但二者表达无明显差异（P>0.05）

胶质细胞瘤中AXL的表达明显高于颅内减压术切除组织及脑膜瘤

具有显著性差异（P<0.05）。结论:AXL在人脑胶质细胞瘤中的表达水平较脑良性肿瘤中高

它的表达与肿瘤的性质有密切的关系。

Abstract

Objective: To investigate the expression of AXL in removed brain tissue of intracranial decompression

human gliomas

human meningiomas and the significance of AXL expression.Methods:31 tissue samples of glioma

25 tissue samples of meningioma patients and 12 removed brain tissue samples of intracranial decompression were collected and expressions of AXL in these tissue were detected using reverse transcriptase polymerase chain reaction(RT-PCR).Results:The positive expressions of AXL was found in removed brain tissue of intracranial decompression and human meningiomas tissue and there was no significant difference in expression between them(P>0.05).The expression of AXL in human gliomas tissue was significantly higher than those in removed brain tissue of intracranial decompression and human meningiomas tissue(P<0.05).Conclusion:The expression of AXL in human brain malignant tumor is higher than in benign tumor

indicating that AXL expression may be closely related to the nature of tumor.

关键词

胶质细胞瘤脑膜瘤AXL

Keywords

GliomameningiomaAXL

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