Optimization of ibuprofen slowly-released in situ gel by uniform design and studies of release behavior

WANG Li-juan; et al

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Optimization of ibuprofen slowly-released in situ gel by uniform design and studies of release behavior

更新时间：2024-01-17

- Optimization of ibuprofen slowly-released in situ gel by uniform design and studies of release behavior
- Journal of Chongqing Medical University Vol. 34, Issue 12, Pages: 1704-1708(2009)
- 作者机构：
  
  重庆医科大学药学院药剂教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R944.5
- Published：2009，
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[1]王丽娟,朱照静,吴青,马俐丽.均匀设计法优选布洛芬缓释原位凝胶剂处方及释药性质的研究[J].重庆医科大学学报,2009,34(12):1704-1708.

WANG Li-juan, et al. Optimization of ibuprofen slowly-released in situ gel by uniform design and studies of release behavior. [J]. Journal of Chongqing Medical University 34(12):1704-1708(2009)
[1]王丽娟,朱照静,吴青,马俐丽.均匀设计法优选布洛芬缓释原位凝胶剂处方及释药性质的研究[J].重庆医科大学学报,2009,34(12):1704-1708. DOI：

WANG Li-juan, et al. Optimization of ibuprofen slowly-released in situ gel by uniform design and studies of release behavior. [J]. Journal of Chongqing Medical University 34(12):1704-1708(2009) DOI：

摘要

目的:用均匀设计法筛选布洛芬缓释原位凝胶剂处方

考察不同处方的凝胶溶蚀和药物释放行为。方法:冷法制备原位凝胶

单因素考察布洛芬-羟丙基-β-环糊精包和物和辅料对胶凝温度（Tsol-ge）l的影响

均匀设计法优化P407和P188浓度

无膜溶出法考察凝胶溶蚀行为

高效液相色谱法对溶蚀液进行定量分析。结果:海藻酸钠随浓度的增大可使Tsol-gel降低

优化后P407/P188=19%/5%

凝胶溶蚀和药物累积释放与时间均呈零级动力学。结论:均匀设计法适合用于筛选P407和P188浓度

制得的原位凝胶具有缓释效果。

Abstract

Objective:To optimize the formula of ibuprofen slowly-released in situ gels and investigate the corrosion of gels and the release of the ibuprofen from the gels.Methods:The in situ gels were prepared by cold method.The effects of IBU-HP-β-CyD and sodium alginate on gelatination temperature(Tsol-gel) were investigated.The concentration of P407 and P188 were optimized by uniform design and the corrosion behavior of gels was studied by membraneless model.The fluid of the corrosion was quantitatively analyzed by HPLC.Results:The Tsol-gel was degraded with the increase of sodium alginate.The optimized concentration of P407/P188 was 19%/5%.The corrosion of gels and the release of the ibuprofen fitted zero-order kinetics.Conclusion:Uniform design is fit to optimize the concentration of P407 and P188.The gels meet the requirement of sustained-release preparation.

关键词

均匀设计泊洛沙姆原位凝胶海藻酸钠无膜溶出

Keywords

Uniform designPoloxamerIn situ gelSodium alginateMembraneless model

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