Complexation of anethol trithione with 2-hydroxypropyl-β-cyclodextrin

OU Yun-guo; et al

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Complexation of anethol trithione with 2-hydroxypropyl-β-cyclodextrin

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- Complexation of anethol trithione with 2-hydroxypropyl-β-cyclodextrin
- Journal of Chongqing Medical University Vol. 34, Issue 10, Pages: 1389-1393(2009)
- 作者机构：
  
  重庆医科大学药学院药剂教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： TQ463.5
- Published：2009，
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[1]欧云国,黄华.茴三硫-2-羟丙基-β-环糊精包合物制备工艺的研究[J].重庆医科大学学报,2009,34(10):1389-1393.

OU Yun-guo, et al. Complexation of anethol trithione with 2-hydroxypropyl-β-cyclodextrin. [J]. Journal of Chongqing Medical University 34(10):1389-1393(2009)
[1]欧云国,黄华.茴三硫-2-羟丙基-β-环糊精包合物制备工艺的研究[J].重庆医科大学学报,2009,34(10):1389-1393. DOI：

OU Yun-guo, et al. Complexation of anethol trithione with 2-hydroxypropyl-β-cyclodextrin. [J]. Journal of Chongqing Medical University 34(10):1389-1393(2009) DOI：

摘要

目的:研究茴三硫-2-羟丙基-β-环糊精（2-Hydroxypropyl-β-cyclodestrin

2-HP-β-CD）包合物制备工艺及2-HP-β-CD对茴三硫的增溶作用。方法:在单因数试验基础上

采用正交试验优化法

以包合率为指标

考察主客分子摩尔比、搅拌速度和搅拌时间等因素对制备包合物的影响;运用热分析法测定包合物中药物的溶解度并对包合物进行验证。结果:结果表明茴三硫-2-羟丙基-β-环糊精包合物对茴三硫具有明显的增溶作用。结论:经过包合后茴三硫包合物的溶解度是原料药460倍。

Abstract

Objective:To study the solubilization effect of 2-hydroxypropyl-β-cyclodextrin(2-HP-β-CD) on anethol trithione and the complexation of anethol trithione with 2-HP-β-CD.Methods:On the basis of single factor experiment

the drug complexed rate was adopted as the index

to study the effects of factors like host-guest molar ratio

alcohol concentration

stiring rate and stiring time on the techniques of preparing anethol trithione-2-HP-β-CD;the inclusion complex was identificated and solubility was detected by diferential scanning calorimeter(DSC) methods.Results:2-HP-β-CD can obviously enhance solubility of anethol trithione.Conclusion:The solubility of inclusion complex increased by 460 times when it was included by 2-HP-β-CD.

关键词

茴三硫包合物溶解度验证

Keywords

Anethol trithioneInclusion complexSolubilityIdentification

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