Study on disintegrating method for simvastatin orally disintegrating tablets

CAI Shuang-shuang; et al

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Study on disintegrating method for simvastatin orally disintegrating tablets

更新时间：2024-01-17

- Study on disintegrating method for simvastatin orally disintegrating tablets
- Journal of Chongqing Medical University Vol. 34, Issue 10, Pages: 1394-1396(2009)
- 作者机构：
  
  重庆医科大学药学院药物化学研究室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R943
- Published：2009，
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[1]蔡双霜,黄华.辛伐他汀口腔崩解片崩解评价方法的考察[J].重庆医科大学学报,2009,34(10):1394-1396.

CAI Shuang-shuang, et al. Study on disintegrating method for simvastatin orally disintegrating tablets. [J]. Journal of Chongqing Medical University 34(10):1394-1396(2009)
[1]蔡双霜,黄华.辛伐他汀口腔崩解片崩解评价方法的考察[J].重庆医科大学学报,2009,34(10):1394-1396. DOI：

CAI Shuang-shuang, et al. Study on disintegrating method for simvastatin orally disintegrating tablets. [J]. Journal of Chongqing Medical University 34(10):1394-1396(2009) DOI：

摘要

目的:对3种体外崩解方法进行评价。方法:利用固态溶液技术制备辛伐他汀口腔崩解片

采用3种方法测定口腔崩解片的体外崩解

并且考查体内外相关性。结果:自行设计的试管倒置法有较好的重现性和体内外崩解时间相关性

滴定管滴液法和冻干测定法效果不是很好。结论:试管倒置法适用于冻干型口腔崩解片的体外崩解检测。

Abstract

Objective:To evaluate three disintegrating equipments for simvastatin orally disintegrating tablet.Methods: Simvastatin orally disintegrating tablets were prepared by solid-states-dissolution technology

and three disintegrating equipments were used to detect the disintegration of orally disintegrating tablets in vitro

and also the relationship between disintegrating results:in vivo and in vitro was studied.Results:Tube inverted method has good reproducibility

in vivo-in vitro relationship and effective control of particle size

but the results of the other two methods were not so good.Conclusion: Tube inverted method is suitable for testing the disintegration of freeze-dreled orally disintegrating tablets in vitro.

关键词

辛伐他汀口腔崩解片冻干片崩解测定体内外相关性

Keywords

Simvastatin orally disintegrating tabletsFreeze-dried tabletsDisintegration testCorelation in vivo and in vitro

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