Objective:To evaluate the effect of thoracic epidural analgesia(TEA)oncoagulation and fibrinolysis dynamic balancein patients undergoing thoracic surgery in perioperative period by means of coagulation and fibrinolysis dynamic-pattern(CF).Methods:Forty patients undergoing thoracotomy(esophageal cancer radical correction and lobectomia pulmonalis)were randomized to receive either combined general-epidural anesthesia(GEA group

n=20)or general anesthesia(GA group

n=20).The fasting antebrachial venous blood of patients were drawn before anesthesia(basic value)

at closing chest and on the 1st and 3rd day after operation respectively to measure Platele(tPLT)

Fibrinogen(FIB)and make coagulation and fibrinolysis dynamic-pattern

and deep venous color doppler ultrasonoscope was done before operation and on the 4th to7th days after operation respectively.Results:FIB

concretion startup time(CST)and maximum extent of coagulation(MCE)had no significant difference between the two groups(P>0.05).At closing chest and after operation

compared with GA group maximum coagulation time(MCT)of GEA group obviously extended(P<0.05)

PLT was significantly decreased(P<0.01)

the balance time(BLT)and the whole time of fibrinolysis reaction(WFT)were obviously shortened(P<0.01).The formation rate of postoperative deep venous thrombosis(DVT)of GEA group was significantly lower than that of GA group(P<0.05).Conclusion:TEA can inhibit increase in coagulation induced by stress

improve postoperative inhibition of fibrinolysis

and keep intracorporal coagulation and fibrinolysis dynamic balance.