Expression of α-catenin and focal adhesion kinase in human colon carcinoma and their relationship with tumor invasion and metastasis

WANG Ji-ming; et al

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Expression of α-catenin and focal adhesion kinase in human colon carcinoma and their relationship with tumor invasion and metastasis

更新时间：2024-01-17

- Expression of α-catenin and focal adhesion kinase in human colon carcinoma and their relationship with tumor invasion and metastasis
- Journal of Chongqing Medical University Vol. 34, Issue 7, Pages: 833-836(2009)
- 作者机构：
  
  1. 重庆医科大学附属第一医院胃肠外科
  2. 重庆市普通外科学重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R735.34
- Published：2009，
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[1]王吉明,程勇,董蒲江,胡祥.结肠癌α-catenin和FAK的表达与侵袭转移的关系[J].重庆医科大学学报,2009,34(07):833-836.

WANG Ji-ming, et al. Expression of α-catenin and focal adhesion kinase in human colon carcinoma and their relationship with tumor invasion and metastasis. [J]. Journal of Chongqing Medical University 34(7):833-836(2009)
[1]王吉明,程勇,董蒲江,胡祥.结肠癌α-catenin和FAK的表达与侵袭转移的关系[J].重庆医科大学学报,2009,34(07):833-836. DOI：

WANG Ji-ming, et al. Expression of α-catenin and focal adhesion kinase in human colon carcinoma and their relationship with tumor invasion and metastasis. [J]. Journal of Chongqing Medical University 34(7):833-836(2009) DOI：

摘要

目的:探讨α-catenin和黏着斑激酶（Focal adhesion kinase

FAK）在结肠癌中的表达特点及临床意义。方法:分别应用免疫组化、Western blot方法来检测34例结肠癌患者肿瘤组织及相应正常组织的α-catenin和FAK的表达。结果:α-catenin和FAK在肿瘤组织和正常组织中均有表达

主要表达于细胞膜和细胞浆。α-catenin的表达在肿瘤组织中明显低于正常组织（t=10.693

P<0.01）

FAK在肿瘤组织中的表达明显高于正常组织（χ2=10.350

P=0.001）

两者在肿瘤组织中的表达呈弱负相关（Pearson相关系数为-0.383

P=0.025）。α-catenin和FAK的表达在结肠癌TNM分期、有无远处转移、和有无淋巴转移方面差异有显著意义（P<0.01）

与患者的年龄、性别之间未发现关系。α-catenin的表达在肿瘤的病理组织分化程度方面差异亦有显著意义

FAK在不同肿瘤病理组织分化程度之间表达没有统计学意义。结论:肿瘤组织中FAK的高表达与α-catenin的低表达

共同在结肠癌的发生发展过程中扮演着重要角色。

Abstract

Objective:To investigate the expression of α-caten in and focal adhesion kinase(FAK)in colon carcinoma and to reveal their correlation with tumor clinicopathological features. Methods:The expression of α-catenin and FAK in tumor tissue and normal tissue of 34 colon carcinoma patients were detected by immunohistochemistry and Western blot.Results:The expression of α-catenin and FAK were detected both in tumor tissue and normal tissue

mostly in plasmalemma and endochylema.The expression of α-catenin was significantly lower in tumor tissue than that in normal tissue(t=10.693

P<0.01)

but the expression of FAK was higher in tumor tissue than that in normal tissue(χ2=10.350

P=0.001). A weak negative correlation was found between FAK and α-catenin(Pearson correlation coefficient=-0.383

P=0.025).The expression of α-catenin and FAK were significantly correlated with TNM staging、distant metastasis and lymph node metastasis of colon carcinoma (P<0.01)

but not with the sex and age of patients.The expression of α-catenin was also related to tumor differentiation status

but the expression of FAK was not statisticaly significant in different tumor differentiation status. Conclusion:The overexpression of FAK and the reduced expression of α-catenin in tumor tissue play an important role in the tumorigenesis and progression of colon carcinoma.

关键词

结肠癌α-连接蛋白黏着斑激酶转移

Keywords

Colonic neoplasmsα-cateninfocal adhesion kinaseNeoplasm metastasis

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