Influence of selective cyclooxygenase-2 inhibitor on growth of human bladder carcinoma

ZHANG Rong-gui; et al

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Influence of selective cyclooxygenase-2 inhibitor on growth of human bladder carcinoma

更新时间：2024-01-17

- Influence of selective cyclooxygenase-2 inhibitor on growth of human bladder carcinoma
- Journal of Chongqing Medical University Vol. 34, Issue 11, Pages: 1524-1526(2009)
- 作者机构：
  
  重庆医科大学附属第二医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：
  CLC： R737.14
- Published：2009，
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[1]张荣贵,张唯力,徐光勇.环氧合酶-2抑制剂美洛昔康对人膀胱癌T24细胞体内外生长的影响[J].重庆医科大学学报,2009,34(11):1524-1526.

ZHANG Rong-gui, et al. Influence of selective cyclooxygenase-2 inhibitor on growth of human bladder carcinoma. [J]. Journal of Chongqing Medical University 34(11):1524-1526(2009)
[1]张荣贵,张唯力,徐光勇.环氧合酶-2抑制剂美洛昔康对人膀胱癌T24细胞体内外生长的影响[J].重庆医科大学学报,2009,34(11):1524-1526. DOI：

ZHANG Rong-gui, et al. Influence of selective cyclooxygenase-2 inhibitor on growth of human bladder carcinoma. [J]. Journal of Chongqing Medical University 34(11):1524-1526(2009) DOI：

摘要

目的:探讨选择性环氧合酶-2（Cyclooxygenase-2

COX-2）抑制剂美洛昔康对膀胱癌T24细胞生长的体内外抑制作用。方法:RT-PCR检测人膀胱癌T24细胞株COX-2 mRNA表达

应用四唑氮蓝还原法研究选择性COX-2抑制剂美洛昔康对膀胱癌细胞T24生长的体外抑制作用。观察美洛昔康对裸鼠T24细胞移植瘤生长的体内抑制作用。结果:膀胱癌细胞株T24中检测出了COX-2的表达

美洛昔康体外抑制膀胱癌细胞株T24的增殖呈剂量依赖性

体内抑瘤率达61.2%。各组裸鼠的体内实验中未见明显不良反应。结论:选择性COX-2抑制剂在体内外对膀胱癌T24细胞生长均具有显著的抑制作用

提示其可用于膀胱癌的防治。

Abstract

Objective:Toinvestigate the effects of selective COX-2 inhibitor on proliferation ofbladder carcinoma in vivoand in vitro.Methods:RT-PCR studied the expression of COX-2 in T24 cell.The inhibitory effects of Meloxicam on the growth of T24 cells were studied in vitro by MTT method.Meanwhile

the inhibitory rate of tumor growth in xenografted bladder carcinoma of T24 cells in nude mice treated by Meloxicam was determined.Results:RT-PCR showed that the expression of C0X-2 mRNA was strong in T24 bladder carcinoma cell.MTT study showed that Meloxicam produced a dose-dependent inhibition of T24 proliferation.The rate of tumor growth inhibition by Meloxicam in T24 cell burden mice was 61.2%.No side effect was observed in all the treatment groups.Conclusion: Selective COX-2 inhibitor can significantly inhibit bladder carcinoma of T24 cells in vivo and in vitro and may be useful for prevention and therapy of bladder carcinoma.

关键词

美洛昔康膀胱癌体内体外

Keywords

MeloxicamBladder carcinomaInvivoInvitro

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重庆医科大学医学影像学研究所

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